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Journals AJP - Cell Physiology Volume 302 Issue 4

Abstract In skeletal muscle, two major types of muscle fibers exist: slow-twitch oxidative (type I) fibers designed for low-intensity long-lasting contractions, and fast-twitch glycolytic (type II) fibers designed for high-intensity short-duration contractions. Such a wide range of capabilities has emerged through the selection across fiber types of a narrow set of molecular characteristics suitable to achieve a specific contractile phenotype. In this article we review evidence supporting the existence of distinct functional phenotypes in mitochondria from slow and fast fibers that may be required to ensure optimal muscle function. This includes differences with respect to energy substrate preferences, regulation of oxidative phosphorylation, dynamics of reactive oxygen species, handling of Ca 2+ , and regulation of cell death. The potential physiological implications on muscle function and the putative mechanisms responsible for establishing and maintaining distinct mitochondrial phenotype across fiber types are also discussed. mitochondria reactive oxygen species calcium retention capacity oxidative capacity Copyright © 2012 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print October 2011 , doi: 10.​1152/​ajpcell.​00368.​2011 Am J Physiol Cell Physiol February 2012 vol. 302 no. 4 C629-C641 » Abstract Free Full Text Full Text (PDF) All Versions of this Article: ajpcell.00368.2011v1 302/4/C629 most recent Classifications Review Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Picard, M. Articles by Burelle, Y. PubMed PubMed citation Articles by Picard, M. Articles by Burelle, Y. Related Content Load related web page information Current Issue February 2012, 302 (4) Alert me to new issues of Am J Physiol Cell Physiol About the Journal Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2012 the American Physiological Society Print ISSN: 0363-6143 Online ISSN: 1522-1563 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview();

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Mitochondrial functional specialization in glycolytic and oxidative muscle fibers: tailoring the organelle for optimal function

Picard, Martin; Hepple, Russell T.; Burelle, Yan
AJP - Cell Physiology , Volume 302 (4): C629
The American Physiological Society – Feb 15, 2012

More Info
  • Publisher American Physiological Society
  • Copyright Copyright © 2012 the American Physiological Society
  • ISSN 0363-6143
  • eISSN 1522-1563
  • D.O.I. 10.1152/ajpcell.00368.2011
  • Publisher site Get PDF  

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