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Blonde-Cynober, F., F. Plassart, J. P. de Bandt, C. Rey, S. K. Lim, N. Moukarbel, F. Ballet, R. Poupon, J. Giboudeau, and L. Cynober. cx-ketoisocaproic acid in isolated perfused liver cirrhotic . Am. J. Physiol. 268 (Endocrinol. Metab. 31): E298-E304, 1995.-To determine the hepatic fate a-ketoisocaproate () in cirrhosis, six groups isolated rat livers were perfused with 0, 0.5, 1 (with or without CY-[Lâ~C]), 2, and 5 mM ; control livers from healthy were studied in parallel under similar conditions. was rapidly removed by the normal livers, whereas uptake was lower in the cirrhotic livers at all concentrations tested (at 2 mM, 4.04 2 0.33 vs. 6.32 * 0.58 kmol/min; P 5 0.05). The transamination pathway, evaluated by leucine exchanges, was more important in the cirrhotic livers (25.4 vs. 6.8% in controls at 2 mM). The incorporation a-[I-14C] in proteins cirrhotic liver was increased compared with controls (0.25 t 0.04% (x-[lJ4C] was incorporated in proteins excreted in perfusate vs. 0.20 t 0.04 in controls; P _< 0.05). In addition, a line evidence suggests that glutamine rather than glutamate is the N donor for leucine synthesis from . The decarboxylation pathway evaluated by P-hydroxybutyrate production and by 14C08 release
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Feb 1, 1995
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