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LPS-mediated endothelial activation in pulmonary endothelial cells: role of Nox2-dependent IKK-β phosphorylation

LPS-mediated endothelial activation in pulmonary endothelial cells: role of Nox2-dependent IKK-β... REFERENCES 1. ↵ Akira S . TLR Signaling . Curr Top Microbiol Immunol 311 : 1 – 16 , 2006 . OpenUrl Medline Web of Science 2. ↵ Al Ghouleh I , Magder S . Nicotinamide adenine dinucleotide phosphate (reduced form) oxidase is important for LPS-induced endothelial cell activation . Shock 29 : 553 – 559 , 2008 . OpenUrl Medline Web of Science 3. ↵ Alom-Ruiz SP , Anilkumar N , Shah AM . Reactive oxygen species and endothelial activation . Antioxid Redox Signal 10 : 1089 – 1100 , 2008 . OpenUrl CrossRef Medline Web of Science 4. ↵ Barisic S , Strozyk E , Peters N , Walczak H , Kulms D . Identification of PP2A as a crucial regulator of the NF-kappaB feedback loop: its inhibition by UVB turns NF-kappaB into a pro-apoptotic factor . Cell Death Differ 15 : 1681 – 1690 , 2008 . OpenUrl CrossRef Medline Web of Science 5. ↵ Bedard K , Krause KH . The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology . Physiol Rev 87 : 245 – 313 , 2007 . OpenUrl Abstract / FREE Full Text 6. ↵ Bose CL , Laughon MM , Dammann CE . Bronchopulmonary dysplasia and inflammatory biomarkers in the premature neonate . Arch Dis Child Fetal Neonatal Ed 93 : F455 – F461 , 2008 . OpenUrl Abstract / FREE Full Text 7. ↵ Brandes RP , Schroder K . Composition and functions of vascular nicotinamide adenine dinucleotide phosphate oxidases . Trends Cardiovasc Med 18 : 15 – 19 , 2008 . OpenUrl CrossRef Medline Web of Science 8. ↵ Brigham KL , Meyrick B , Berry LC Jr . , Repine JE . Antioxidants protect cultured bovine lung endothelial cells from injury by endotoxin . J Appl Physiol 63 : 840 – 850 , 1987 . OpenUrl Abstract / FREE Full Text 9. ↵ Carnesecchi S , Pache JC , Barazzone-Argiroffo C . NOX enzymes: potential target for the treatment of acute lung injury . Cell Mol Life Sci 69 : 2373 – 2385 , 2012 . OpenUrl CrossRef Medline 10. ↵ Carpenter S , O'Neill LA . Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins . Biochem J 422 : 1 – 10 , 2009 . OpenUrl CrossRef Medline Web of Science 11. ↵ Chen YH , Lin SJ , Chen YL , Liu PL , Chen JW . Anti-inflammatory effects of different drugs/agents with antioxidant property on endothelial expression of adhesion molecules . Cardiovasc Hematol Disord Drug Targets 6 : 279 – 304 , 2006 . OpenUrl Medline 12. ↵ Dada LA , Sznajder JI . Mitochondrial Ca(2)+ and ROS take center stage to orchestrate TNF-alpha-mediated inflammatory responses . J Clin Invest 121 : 1683 – 1685 , 2011 . OpenUrl CrossRef Medline Web of Science 13. ↵ Delhase M , Hayakawa M , Chen Y , Karin M . Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation . Science 284 : 309 – 313 , 1999 . OpenUrl Abstract / FREE Full Text 14. ↵ Fanaroff AA , Stoll BJ , Wright LL , Carlo WA , Ehrenkranz RA , Stark AR , Bauer CR , Donovan EF , Korones SB , Laptook AR , Lemons JA , Oh W , Papile LA , Shankaran S , Stevenson DK , Tyson JE , Poole WK . Trends in neonatal morbidity and mortality for very low birthweight infants . Am J Obstet Gynecol 196 : 147 e141 – e148 , 2007 . OpenUrl 15. ↵ Hacker H , Karin M . Regulation and function of IKK and IKK-related kinases . Sci STKE 2006 : re13 , 2006 . OpenUrl Abstract / FREE Full Text 16. ↵ Heumuller S , Wind S , Barbosa-Sicard E , Schmidt HH , Busse R , Schroder K , Brandes RP . Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant . Hypertension 51 : 211 – 217 , 2008 . OpenUrl CrossRef 17. ↵ Holden P , Horton WA . Crude subcellular fractionation of cultured mammalian cell lines . BMC Res Notes 2 : 243 , 2009 . OpenUrl CrossRef Medline 18. ↵ Inagaki M , Omori E , Kim JY , Komatsu Y , Scott G , Ray MK , Yamada G , Matsumoto K , Mishina Y , Ninomiya-Tsuji J . TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling . J Biol Chem 283 : 33080 – 33086 , 2008 . OpenUrl Abstract / FREE Full Text 19. ↵ Irani K . Oxidant signaling in vascular cell growth, death, and survival: a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling . Circ Res 87 : 179 – 183 , 2000 . OpenUrl Abstract / FREE Full Text 20. ↵ Jaspers I , Zhang W , Fraser A , Samet JM , Reed W . Hydrogen peroxide has opposing effects on IKK activity and IkappaBalpha breakdown in airway epithelial cells . Am J Respir Cell Mol Biol 24 : 769 – 777 , 2001 . OpenUrl Abstract / FREE Full Text 21. ↵ Johnson LN , Noble ME , Owen DJ . Active and inactive protein kinases: structural basis for regulation . Cell 85 : 149 – 158 , 1996 . OpenUrl CrossRef Medline Web of Science 22. ↵ Kajino-Sakamoto R , Omori E , Nighot PK , Blikslager AT , Matsumoto K , Ninomiya-Tsuji J . TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epithelium . J Immunol 185 : 4729 – 4737 . 23. ↵ Kandasamy K , Sahu G , Parthasarathi K . Real-time imaging reveals endothelium-mediated leukocyte retention in LPS-treated lung microvessels . Microvasc Res 83 : 323 – 331 , 2012 . OpenUrl CrossRef Medline 24. ↵ Kim SI , Kwak JH , Na HJ , Kim JK , Ding Y , Choi ME . Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells . J Biol Chem 284 : 22285 – 22296 , 2009 . OpenUrl Abstract / FREE Full Text 25. ↵ Kim SY , Lee JG , Cho WS , Cho KH , Sakong J , Kim JR , Chin BR , Baek SH . Role of NADPH oxidase-2 in lipopolysaccharide-induced matrix metalloproteinase expression and cell migration . Immunol Cell Biol 88 : 197 – 204 . 26. ↵ Korn SH , Wouters EF , Vos N , Janssen-Heininger YM . Cytokine-induced activation of nuclear factor-kappa B is inhibited by hydrogen peroxide through oxidative inactivation of IkappaB kinase . J Biol Chem 276 : 35693 – 35700 , 2001 . OpenUrl Abstract / FREE Full Text 27. ↵ Kray AE , Carter RS , Pennington KN , Gomez RJ , Sanders LE , Llanes JM , Khan WN , Ballard DW , Wadzinski BE . Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A . J Biol Chem 280 : 35974 – 35982 , 2005 . OpenUrl Abstract / FREE Full Text 28. ↵ Lassegue B , Clempus RE . Vascular NAD(P)H oxidases: specific features, expression, and regulation . Am J Physiol Regul Integr Comp Physiol 285 : R277 – R297 , 2003 . OpenUrl Abstract / FREE Full Text 29. ↵ Lee J , Mira-Arbibe L , Ulevitch RJ . TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide . J Leukoc Biol 68 : 909 – 915 , 2000 . OpenUrl Abstract / FREE Full Text 30. ↵ Levrand S , Pesse B , Feihl F , Waeber B , Pacher P , Rolli J , Schaller MD , Liaudet L . Peroxynitrite is a potent inhibitor of NF-(kappa)B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines . J Biol Chem 280 : 34878 – 34887 , 2005 . OpenUrl Abstract / FREE Full Text 31. ↵ Li JM , Shah AM . Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology . Am J Physiol Regul Integr Comp Physiol 287 : R1014 – R1030 , 2004 . OpenUrl Abstract / FREE Full Text 32. ↵ Li Q , Harraz MM , Zhou W , Zhang LN , Ding W , Zhang Y , Eggleston T , Yeaman C , Banfi B , Engelhardt JF . Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes . Mol Cell Biol 26 : 140 – 154 , 2006 . OpenUrl Abstract / FREE Full Text 33. ↵ Li Q , Spencer NY , Oakley FD , Buettner GR , Engelhardt J . Endosomal Nox2 facilitates redox-dependent induction of NFκB by TNFalpha . Antiox Redox Signal 11 : 1249 – 1263 , 2009 . OpenUrl CrossRef Medline Web of Science 34. ↵ Loukili N , Rosenblatt-Velin N , Rolli J , Levrand S , Feihl F , Waeber B , Pacher P , Liaudet L . Oxidants positively or negatively regulate nuclear factor kappaB in a context-dependent manner . J Biol Chem 285 : 15746 – 15752 . 35. ↵ Matute-Bello G , Frevert CW , Martin TR . Animal models of acute lung injury . Am J Physiol Lung Cell Mol Physiol 295 : L379 – L399 , 2008 . OpenUrl Abstract / FREE Full Text 36. ↵ Miyoshi T , Yamashita K , Arai T , Yamamoto K , Mizugishi K , Uchiyama T . The role of endothelial interleukin-8/NADPH oxidase 1 axis in sepsis . Immunology 131 : 331 – 339 , 2010 . OpenUrl CrossRef Medline Web of Science 37. ↵ Ninomiya-Tsuji J , Kajino T , Ono K , Ohtomo T , Matsumoto M , Shiina M , Mihara M , Tsuchiya M , Matsumoto K . A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase . J Biol Chem 278 : 18485 – 18490 , 2003 . OpenUrl Abstract / FREE Full Text 38. ↵ Ogier-Denis E , Mkaddem SB , Vandewalle A . NOX enzymes and Toll-like receptor signaling . Semin Immunopathol 30 : 291 – 300 , 2008 . OpenUrl Medline 39. ↵ Omori E , Inagaki M , Mishina Y , Matsumoto K , Ninomiya-Tsuji J . Epithelial transforming growth factor beta-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species . Proc Natl Acad Sci USA 109 : 3365 – 3370 , 2012 . OpenUrl Abstract / FREE Full Text 40. ↵ Omori E , Morioka S , Matsumoto K , Ninomiya-Tsuji J . TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity . J Biol Chem 283 : 26161 – 26168 , 2008 . OpenUrl Abstract / FREE Full Text 41. ↵ Park HS , Chun JN , Jung HY , Choi C , Bae YS . Role of NADPH oxidase 4 in lipopolysaccharide-induced proinflammatory responses by human aortic endothelial cells . Cardiovasc Res 72 : 447 – 455 , 2006 . OpenUrl Abstract / FREE Full Text 42. ↵ Park HS , Jung HY , Park EY , Kim J , Lee WJ , Bae YS . Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B . J Immunol 173 : 3589 – 3593 , 2004 . OpenUrl Abstract / FREE Full Text 43. ↵ Paterniti I , Galuppo M , Mazzon E , Impellizzeri D , Esposito E , Bramanti P , Cuzzocrea S . Protective effects of apocynin, an inhibitor of NADPH oxidase activity, in splanchnic artery occlusion and reperfusion . J Leukoc Biol 88 : 993 – 1003 , 2010 . OpenUrl CrossRef Medline Web of Science 44. ↵ Prickett TD , Ninomiya-Tsuji J , Broglie P , Muratore-Schroeder TL , Shabanowitz J , Hunt DF , Brautigan DL . TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB . J Biol Chem 283 : 19245 – 19254 , 2008 . OpenUrl Abstract / FREE Full Text 45. ↵ Ramsay PL , O'Brian Smith E , Hegemier S , Welty SE . Early clinical markers for the development of bronchopulmonary dysplasia: soluble E-Selectin and ICAM-1 . Pediatrics 102 : 927 – 932 , 1998 . OpenUrl Abstract / FREE Full Text 46. ↵ Reynaert NL , van der Vliet A , Guala AS , McGovern T , Hristova M , Pantano C , Heintz NH , Heim J , Ho YS , Matthews DE , Wouters EF , Janssen-Heininger YM . Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta . Proc Natl Acad Sci USA 103 : 13086 – 13091 , 2006 . OpenUrl Abstract / FREE Full Text 47. ↵ Rossi A , Kapahi P , Natoli G , Takahashi T , Chen Y , Karin M , Santoro MG . Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase . Nature 403 : 103 – 108 , 2000 . OpenUrl CrossRef Medline 48. ↵ Schmid JA , Birbach A . IkappaB kinase beta (IKKbeta/IKK2/IKBKB)–a key molecule in signaling to the transcription factor NF-kappaB . Cytokine Growth Factor Rev 19 : 157 – 165 , 2008 . OpenUrl CrossRef Medline Web of Science 49. ↵ Schmittgen TD , Livak KJ . Analyzing real-time PCR data by the comparative C(T) method . Nat Protocol 3 : 1101 – 1108 , 2008 . OpenUrl CrossRef 50. ↵ Shanley TP , Vasi N , Denenberg A , Wong HR . The serine/threonine phosphatase, PP2A: endogenous regulator of inflammatory cell signaling . J Immunol 166 : 966 – 972 , 2001 . OpenUrl Abstract / FREE Full Text 51. ↵ Singhirunnusorn P , Suzuki S , Kawasaki N , Saiki I , Sakurai H . Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2 . J Biol Chem 280 : 7359 – 7368 , 2005 . OpenUrl Abstract / FREE Full Text 52. ↵ Stielow C , Catar RA , Muller G , Wingler K , Scheurer P , Schmidt HH , Morawietz H . Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells . Biochem Biophys Res Commun 344 : 200 – 205 , 2006 . OpenUrl CrossRef Medline Web of Science 53. ↵ Sun QA , Hess DT , Wang B , Miyagi M , Stamler JS . Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine (VAS2870) . Free Radic Biol Med 52 : 1897 – 1902 , 2012 . OpenUrl CrossRef Medline 54. ↵ Takac I , Schroder K , Brandes RP . The Nox family of NADPH oxidases: friend or foe of the vascular system? Curr Hyperten Rep 14 : 70 – 78 , 2012 . OpenUrl CrossRef 55. ↵ ten Freyhaus H , Huntgeburth M , Wingler K , Schnitker J , Baumer AT , Vantler M , Bekhite MM , Wartenberg M , Sauer H , Rosenkranz S . Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation . Cardiovasc Res 71 : 331 – 341 , 2006 . OpenUrl Abstract / FREE Full Text 56. ↵ Thebaud B , Abman SH . Bronchopulmonary dysplasia: where have all the vessels gone? Roles of angiogenic growth factors in chronic lung disease . Am J Respir Crit Care Med 175 : 978 – 985 , 2007 . OpenUrl Abstract / FREE Full Text 57. ↵ Wang W , Wei W , Ning Q , Luo XP . (Effect of intra-amniotic endotoxin priming plus hyperoxic exposure on the expression of vascular endothelial growth factor and its receptors in lungs of preterm newborn rats) . Zhonghua Ke Za Zhi 45 : 533 – 538 , 2007 . OpenUrl 58. ↵ Yang L , Froio RM , Sciuto TE , Dvorak AM , Alon R , Luscinskas FW . ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow . Blood 106 : 584 – 592 , 2005 . OpenUrl Abstract / FREE Full Text 59. ↵ Yao J , Kim TW , Qin J , Jiang Z , Qian Y , Xiao H , Lu Y , Qian W , Gulen MF , Sizemore N , DiDonato J , Sato S , Akira S , Su B , Li X . Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification . J Biol Chem 282 : 6075 – 6089 , 2007 . OpenUrl Abstract / FREE Full Text 60. ↵ Zhao H , Joseph J , Fales HM , Sokoloski EA , Levine RL , Vasquez-Vivar J , Kalyanaraman B . Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence . Proc Natl Acad Sci USA 102 : 5727 – 5732 , 2005 . OpenUrl Abstract / FREE Full Text Previous Next Back to top About the Cover About the Cover Cover image Image 1: Livraghi-Butrico A, Kelly EJ, Wilkinson KJ, Rogers TD, Gilmore RC, Harkema JR, Randell SH, Boucher RC, O'Neal WK, Grubb BR. Loss of Cftr function exacerbates the phenotype of Na + hyperabsorption in murine airways . Am J Physiol Lung Cell Mol Physiol ; published ahead of print February 1, 2013, doi:10.1152/ajplung.00150.2012. Image 2: Gally F, Kosmider B, Weaver MR, Pate KM, Hartshorn KL, Oberley-Deegan RE. FABP5 deficiency enhances susceptibility to H1N1 influenza A virus-induced lung inflammation . Am J Physiol Lung Cell Mol Physiol ; published ahead of print April 26, 2013, doi:10.1152/ajplung.00276.2012. Image 3: Dickinson MG, Bartelds B, Borgdorff MAJ, Berger RMF. The role of disturbed blood flow in the development of pulmonary arterial hypertension: lessons from preclinical animal models . Am J Physiol Lung Cell Mol Physiol ; published ahead of print April 26, 2013, doi:10.1152/ajplung.00031.2013. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords lipopolysaccharide lung endothelial cells NADPH oxidase 2 intercellular adhesion molecule-1 inhibitor of κ-B kinase-β phosphorylation TGF-β associated kinase-1 Article Abstract MATERIALS AND METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Lung Cellular and Molecular Physiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. 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Your Personal Message Print Citation Tools LPS-mediated endothelial activation in pulmonary endothelial cells: role of Nox2-dependent IKK-β phosphorylation Heather Menden , Everett Tate , Neil Hogg , Venkatesh Sampath American Journal of Physiology - Lung Cellular and Molecular Physiology Mar 2013, 304 (6) L445-L455; DOI: 10.1152/ajplung.00261.2012 Citation Manager Formats BibTeX EndNote (tagged) EndNote 8 (xml) RefWorks Tagged RIS Medlars Bookends Mendeley Request Permissions Share LPS-mediated endothelial activation in pulmonary endothelial cells: role of Nox2-dependent IKK-β phosphorylation LPS-mediated endothelial activation in pulmonary endothelial cells: role of Nox2-dependent IKK-β phosphorylation Heather Menden , Everett Tate , Neil Hogg , Venkatesh Sampath American Journal of Physiology - Lung Cellular and Molecular Physiology Mar 2013, 304 (6) L445-L455; DOI: 10.1152/ajplung.00261.2012 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Sustained hyperoxia-induced NF-κB activation improves survival and preserves lung development in neonatal mice Hypoxia-induced mitogenic factor (FIZZ1/RELMα) induces endothelial cell apoptosis and subsequent interleukin-4-dependent pulmonary hypertension Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development Show more Articles Related Articles No related articles found. 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LPS-mediated endothelial activation in pulmonary endothelial cells: role of Nox2-dependent IKK-β phosphorylation

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Publisher
The American Physiological Society
Copyright
Copyright © 2013 the American Physiological Society
ISSN
1040-0605
eISSN
1522-1504
DOI
10.1152/ajplung.00261.2012
pmid
23333803
Publisher site
See Article on Publisher Site

Abstract

REFERENCES 1. ↵ Akira S . TLR Signaling . Curr Top Microbiol Immunol 311 : 1 – 16 , 2006 . OpenUrl Medline Web of Science 2. ↵ Al Ghouleh I , Magder S . Nicotinamide adenine dinucleotide phosphate (reduced form) oxidase is important for LPS-induced endothelial cell activation . Shock 29 : 553 – 559 , 2008 . OpenUrl Medline Web of Science 3. ↵ Alom-Ruiz SP , Anilkumar N , Shah AM . Reactive oxygen species and endothelial activation . Antioxid Redox Signal 10 : 1089 – 1100 , 2008 . OpenUrl CrossRef Medline Web of Science 4. ↵ Barisic S , Strozyk E , Peters N , Walczak H , Kulms D . Identification of PP2A as a crucial regulator of the NF-kappaB feedback loop: its inhibition by UVB turns NF-kappaB into a pro-apoptotic factor . Cell Death Differ 15 : 1681 – 1690 , 2008 . OpenUrl CrossRef Medline Web of Science 5. ↵ Bedard K , Krause KH . The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology . Physiol Rev 87 : 245 – 313 , 2007 . OpenUrl Abstract / FREE Full Text 6. ↵ Bose CL , Laughon MM , Dammann CE . Bronchopulmonary dysplasia and inflammatory biomarkers in the premature neonate . Arch Dis Child Fetal Neonatal Ed 93 : F455 – F461 , 2008 . OpenUrl Abstract / FREE Full Text 7. ↵ Brandes RP , Schroder K . Composition and functions of vascular nicotinamide adenine dinucleotide phosphate oxidases . Trends Cardiovasc Med 18 : 15 – 19 , 2008 . OpenUrl CrossRef Medline Web of Science 8. ↵ Brigham KL , Meyrick B , Berry LC Jr . , Repine JE . Antioxidants protect cultured bovine lung endothelial cells from injury by endotoxin . J Appl Physiol 63 : 840 – 850 , 1987 . OpenUrl Abstract / FREE Full Text 9. ↵ Carnesecchi S , Pache JC , Barazzone-Argiroffo C . NOX enzymes: potential target for the treatment of acute lung injury . Cell Mol Life Sci 69 : 2373 – 2385 , 2012 . OpenUrl CrossRef Medline 10. ↵ Carpenter S , O'Neill LA . Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins . Biochem J 422 : 1 – 10 , 2009 . OpenUrl CrossRef Medline Web of Science 11. ↵ Chen YH , Lin SJ , Chen YL , Liu PL , Chen JW . Anti-inflammatory effects of different drugs/agents with antioxidant property on endothelial expression of adhesion molecules . Cardiovasc Hematol Disord Drug Targets 6 : 279 – 304 , 2006 . OpenUrl Medline 12. ↵ Dada LA , Sznajder JI . Mitochondrial Ca(2)+ and ROS take center stage to orchestrate TNF-alpha-mediated inflammatory responses . J Clin Invest 121 : 1683 – 1685 , 2011 . OpenUrl CrossRef Medline Web of Science 13. ↵ Delhase M , Hayakawa M , Chen Y , Karin M . Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation . Science 284 : 309 – 313 , 1999 . OpenUrl Abstract / FREE Full Text 14. ↵ Fanaroff AA , Stoll BJ , Wright LL , Carlo WA , Ehrenkranz RA , Stark AR , Bauer CR , Donovan EF , Korones SB , Laptook AR , Lemons JA , Oh W , Papile LA , Shankaran S , Stevenson DK , Tyson JE , Poole WK . Trends in neonatal morbidity and mortality for very low birthweight infants . Am J Obstet Gynecol 196 : 147 e141 – e148 , 2007 . OpenUrl 15. ↵ Hacker H , Karin M . Regulation and function of IKK and IKK-related kinases . Sci STKE 2006 : re13 , 2006 . OpenUrl Abstract / FREE Full Text 16. ↵ Heumuller S , Wind S , Barbosa-Sicard E , Schmidt HH , Busse R , Schroder K , Brandes RP . Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant . Hypertension 51 : 211 – 217 , 2008 . OpenUrl CrossRef 17. ↵ Holden P , Horton WA . Crude subcellular fractionation of cultured mammalian cell lines . BMC Res Notes 2 : 243 , 2009 . OpenUrl CrossRef Medline 18. ↵ Inagaki M , Omori E , Kim JY , Komatsu Y , Scott G , Ray MK , Yamada G , Matsumoto K , Mishina Y , Ninomiya-Tsuji J . TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling . J Biol Chem 283 : 33080 – 33086 , 2008 . OpenUrl Abstract / FREE Full Text 19. ↵ Irani K . Oxidant signaling in vascular cell growth, death, and survival: a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling . Circ Res 87 : 179 – 183 , 2000 . OpenUrl Abstract / FREE Full Text 20. ↵ Jaspers I , Zhang W , Fraser A , Samet JM , Reed W . Hydrogen peroxide has opposing effects on IKK activity and IkappaBalpha breakdown in airway epithelial cells . Am J Respir Cell Mol Biol 24 : 769 – 777 , 2001 . OpenUrl Abstract / FREE Full Text 21. ↵ Johnson LN , Noble ME , Owen DJ . Active and inactive protein kinases: structural basis for regulation . Cell 85 : 149 – 158 , 1996 . OpenUrl CrossRef Medline Web of Science 22. ↵ Kajino-Sakamoto R , Omori E , Nighot PK , Blikslager AT , Matsumoto K , Ninomiya-Tsuji J . TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epithelium . J Immunol 185 : 4729 – 4737 . 23. ↵ Kandasamy K , Sahu G , Parthasarathi K . Real-time imaging reveals endothelium-mediated leukocyte retention in LPS-treated lung microvessels . Microvasc Res 83 : 323 – 331 , 2012 . OpenUrl CrossRef Medline 24. ↵ Kim SI , Kwak JH , Na HJ , Kim JK , Ding Y , Choi ME . Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells . J Biol Chem 284 : 22285 – 22296 , 2009 . OpenUrl Abstract / FREE Full Text 25. ↵ Kim SY , Lee JG , Cho WS , Cho KH , Sakong J , Kim JR , Chin BR , Baek SH . Role of NADPH oxidase-2 in lipopolysaccharide-induced matrix metalloproteinase expression and cell migration . Immunol Cell Biol 88 : 197 – 204 . 26. ↵ Korn SH , Wouters EF , Vos N , Janssen-Heininger YM . Cytokine-induced activation of nuclear factor-kappa B is inhibited by hydrogen peroxide through oxidative inactivation of IkappaB kinase . J Biol Chem 276 : 35693 – 35700 , 2001 . OpenUrl Abstract / FREE Full Text 27. ↵ Kray AE , Carter RS , Pennington KN , Gomez RJ , Sanders LE , Llanes JM , Khan WN , Ballard DW , Wadzinski BE . Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A . J Biol Chem 280 : 35974 – 35982 , 2005 . OpenUrl Abstract / FREE Full Text 28. ↵ Lassegue B , Clempus RE . Vascular NAD(P)H oxidases: specific features, expression, and regulation . Am J Physiol Regul Integr Comp Physiol 285 : R277 – R297 , 2003 . OpenUrl Abstract / FREE Full Text 29. ↵ Lee J , Mira-Arbibe L , Ulevitch RJ . TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide . J Leukoc Biol 68 : 909 – 915 , 2000 . OpenUrl Abstract / FREE Full Text 30. ↵ Levrand S , Pesse B , Feihl F , Waeber B , Pacher P , Rolli J , Schaller MD , Liaudet L . Peroxynitrite is a potent inhibitor of NF-(kappa)B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines . J Biol Chem 280 : 34878 – 34887 , 2005 . OpenUrl Abstract / FREE Full Text 31. ↵ Li JM , Shah AM . Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology . Am J Physiol Regul Integr Comp Physiol 287 : R1014 – R1030 , 2004 . OpenUrl Abstract / FREE Full Text 32. ↵ Li Q , Harraz MM , Zhou W , Zhang LN , Ding W , Zhang Y , Eggleston T , Yeaman C , Banfi B , Engelhardt JF . Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes . Mol Cell Biol 26 : 140 – 154 , 2006 . OpenUrl Abstract / FREE Full Text 33. ↵ Li Q , Spencer NY , Oakley FD , Buettner GR , Engelhardt J . Endosomal Nox2 facilitates redox-dependent induction of NFκB by TNFalpha . Antiox Redox Signal 11 : 1249 – 1263 , 2009 . OpenUrl CrossRef Medline Web of Science 34. ↵ Loukili N , Rosenblatt-Velin N , Rolli J , Levrand S , Feihl F , Waeber B , Pacher P , Liaudet L . Oxidants positively or negatively regulate nuclear factor kappaB in a context-dependent manner . J Biol Chem 285 : 15746 – 15752 . 35. ↵ Matute-Bello G , Frevert CW , Martin TR . Animal models of acute lung injury . Am J Physiol Lung Cell Mol Physiol 295 : L379 – L399 , 2008 . OpenUrl Abstract / FREE Full Text 36. ↵ Miyoshi T , Yamashita K , Arai T , Yamamoto K , Mizugishi K , Uchiyama T . The role of endothelial interleukin-8/NADPH oxidase 1 axis in sepsis . Immunology 131 : 331 – 339 , 2010 . OpenUrl CrossRef Medline Web of Science 37. ↵ Ninomiya-Tsuji J , Kajino T , Ono K , Ohtomo T , Matsumoto M , Shiina M , Mihara M , Tsuchiya M , Matsumoto K . A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase . J Biol Chem 278 : 18485 – 18490 , 2003 . OpenUrl Abstract / FREE Full Text 38. ↵ Ogier-Denis E , Mkaddem SB , Vandewalle A . NOX enzymes and Toll-like receptor signaling . Semin Immunopathol 30 : 291 – 300 , 2008 . OpenUrl Medline 39. ↵ Omori E , Inagaki M , Mishina Y , Matsumoto K , Ninomiya-Tsuji J . Epithelial transforming growth factor beta-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species . Proc Natl Acad Sci USA 109 : 3365 – 3370 , 2012 . OpenUrl Abstract / FREE Full Text 40. ↵ Omori E , Morioka S , Matsumoto K , Ninomiya-Tsuji J . TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity . J Biol Chem 283 : 26161 – 26168 , 2008 . OpenUrl Abstract / FREE Full Text 41. ↵ Park HS , Chun JN , Jung HY , Choi C , Bae YS . Role of NADPH oxidase 4 in lipopolysaccharide-induced proinflammatory responses by human aortic endothelial cells . Cardiovasc Res 72 : 447 – 455 , 2006 . OpenUrl Abstract / FREE Full Text 42. ↵ Park HS , Jung HY , Park EY , Kim J , Lee WJ , Bae YS . Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B . J Immunol 173 : 3589 – 3593 , 2004 . OpenUrl Abstract / FREE Full Text 43. ↵ Paterniti I , Galuppo M , Mazzon E , Impellizzeri D , Esposito E , Bramanti P , Cuzzocrea S . Protective effects of apocynin, an inhibitor of NADPH oxidase activity, in splanchnic artery occlusion and reperfusion . J Leukoc Biol 88 : 993 – 1003 , 2010 . OpenUrl CrossRef Medline Web of Science 44. ↵ Prickett TD , Ninomiya-Tsuji J , Broglie P , Muratore-Schroeder TL , Shabanowitz J , Hunt DF , Brautigan DL . TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB . J Biol Chem 283 : 19245 – 19254 , 2008 . OpenUrl Abstract / FREE Full Text 45. ↵ Ramsay PL , O'Brian Smith E , Hegemier S , Welty SE . Early clinical markers for the development of bronchopulmonary dysplasia: soluble E-Selectin and ICAM-1 . Pediatrics 102 : 927 – 932 , 1998 . OpenUrl Abstract / FREE Full Text 46. ↵ Reynaert NL , van der Vliet A , Guala AS , McGovern T , Hristova M , Pantano C , Heintz NH , Heim J , Ho YS , Matthews DE , Wouters EF , Janssen-Heininger YM . Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta . Proc Natl Acad Sci USA 103 : 13086 – 13091 , 2006 . OpenUrl Abstract / FREE Full Text 47. ↵ Rossi A , Kapahi P , Natoli G , Takahashi T , Chen Y , Karin M , Santoro MG . Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase . Nature 403 : 103 – 108 , 2000 . OpenUrl CrossRef Medline 48. ↵ Schmid JA , Birbach A . IkappaB kinase beta (IKKbeta/IKK2/IKBKB)–a key molecule in signaling to the transcription factor NF-kappaB . Cytokine Growth Factor Rev 19 : 157 – 165 , 2008 . OpenUrl CrossRef Medline Web of Science 49. ↵ Schmittgen TD , Livak KJ . Analyzing real-time PCR data by the comparative C(T) method . Nat Protocol 3 : 1101 – 1108 , 2008 . OpenUrl CrossRef 50. ↵ Shanley TP , Vasi N , Denenberg A , Wong HR . The serine/threonine phosphatase, PP2A: endogenous regulator of inflammatory cell signaling . J Immunol 166 : 966 – 972 , 2001 . OpenUrl Abstract / FREE Full Text 51. ↵ Singhirunnusorn P , Suzuki S , Kawasaki N , Saiki I , Sakurai H . Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2 . J Biol Chem 280 : 7359 – 7368 , 2005 . OpenUrl Abstract / FREE Full Text 52. ↵ Stielow C , Catar RA , Muller G , Wingler K , Scheurer P , Schmidt HH , Morawietz H . Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells . Biochem Biophys Res Commun 344 : 200 – 205 , 2006 . OpenUrl CrossRef Medline Web of Science 53. ↵ Sun QA , Hess DT , Wang B , Miyagi M , Stamler JS . Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine (VAS2870) . Free Radic Biol Med 52 : 1897 – 1902 , 2012 . OpenUrl CrossRef Medline 54. ↵ Takac I , Schroder K , Brandes RP . The Nox family of NADPH oxidases: friend or foe of the vascular system? Curr Hyperten Rep 14 : 70 – 78 , 2012 . OpenUrl CrossRef 55. ↵ ten Freyhaus H , Huntgeburth M , Wingler K , Schnitker J , Baumer AT , Vantler M , Bekhite MM , Wartenberg M , Sauer H , Rosenkranz S . Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation . Cardiovasc Res 71 : 331 – 341 , 2006 . OpenUrl Abstract / FREE Full Text 56. ↵ Thebaud B , Abman SH . Bronchopulmonary dysplasia: where have all the vessels gone? Roles of angiogenic growth factors in chronic lung disease . Am J Respir Crit Care Med 175 : 978 – 985 , 2007 . OpenUrl Abstract / FREE Full Text 57. ↵ Wang W , Wei W , Ning Q , Luo XP . (Effect of intra-amniotic endotoxin priming plus hyperoxic exposure on the expression of vascular endothelial growth factor and its receptors in lungs of preterm newborn rats) . Zhonghua Ke Za Zhi 45 : 533 – 538 , 2007 . OpenUrl 58. ↵ Yang L , Froio RM , Sciuto TE , Dvorak AM , Alon R , Luscinskas FW . ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow . Blood 106 : 584 – 592 , 2005 . OpenUrl Abstract / FREE Full Text 59. ↵ Yao J , Kim TW , Qin J , Jiang Z , Qian Y , Xiao H , Lu Y , Qian W , Gulen MF , Sizemore N , DiDonato J , Sato S , Akira S , Su B , Li X . Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification . J Biol Chem 282 : 6075 – 6089 , 2007 . OpenUrl Abstract / FREE Full Text 60. ↵ Zhao H , Joseph J , Fales HM , Sokoloski EA , Levine RL , Vasquez-Vivar J , Kalyanaraman B . Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence . Proc Natl Acad Sci USA 102 : 5727 – 5732 , 2005 . OpenUrl Abstract / FREE Full Text Previous Next Back to top About the Cover About the Cover Cover image Image 1: Livraghi-Butrico A, Kelly EJ, Wilkinson KJ, Rogers TD, Gilmore RC, Harkema JR, Randell SH, Boucher RC, O'Neal WK, Grubb BR. Loss of Cftr function exacerbates the phenotype of Na + hyperabsorption in murine airways . Am J Physiol Lung Cell Mol Physiol ; published ahead of print February 1, 2013, doi:10.1152/ajplung.00150.2012. Image 2: Gally F, Kosmider B, Weaver MR, Pate KM, Hartshorn KL, Oberley-Deegan RE. FABP5 deficiency enhances susceptibility to H1N1 influenza A virus-induced lung inflammation . Am J Physiol Lung Cell Mol Physiol ; published ahead of print April 26, 2013, doi:10.1152/ajplung.00276.2012. Image 3: Dickinson MG, Bartelds B, Borgdorff MAJ, Berger RMF. The role of disturbed blood flow in the development of pulmonary arterial hypertension: lessons from preclinical animal models . Am J Physiol Lung Cell Mol Physiol ; published ahead of print April 26, 2013, doi:10.1152/ajplung.00031.2013. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords lipopolysaccharide lung endothelial cells NADPH oxidase 2 intercellular adhesion molecule-1 inhibitor of κ-B kinase-β phosphorylation TGF-β associated kinase-1 Article Abstract MATERIALS AND METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Lung Cellular and Molecular Physiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. 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Your Personal Message Print Citation Tools LPS-mediated endothelial activation in pulmonary endothelial cells: role of Nox2-dependent IKK-β phosphorylation Heather Menden , Everett Tate , Neil Hogg , Venkatesh Sampath American Journal of Physiology - Lung Cellular and Molecular Physiology Mar 2013, 304 (6) L445-L455; DOI: 10.1152/ajplung.00261.2012 Citation Manager Formats BibTeX EndNote (tagged) EndNote 8 (xml) RefWorks Tagged RIS Medlars Bookends Mendeley Request Permissions Share LPS-mediated endothelial activation in pulmonary endothelial cells: role of Nox2-dependent IKK-β phosphorylation LPS-mediated endothelial activation in pulmonary endothelial cells: role of Nox2-dependent IKK-β phosphorylation Heather Menden , Everett Tate , Neil Hogg , Venkatesh Sampath American Journal of Physiology - Lung Cellular and Molecular Physiology Mar 2013, 304 (6) L445-L455; DOI: 10.1152/ajplung.00261.2012 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Sustained hyperoxia-induced NF-κB activation improves survival and preserves lung development in neonatal mice Hypoxia-induced mitogenic factor (FIZZ1/RELMα) induces endothelial cell apoptosis and subsequent interleukin-4-dependent pulmonary hypertension Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development Show more Articles Related Articles No related articles found. 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Published: Mar 15, 2013

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