Liver regeneration after partial hepatectomy: inconsistent results of expression screenings for human, mouse, and rat microRNAs Nathanael Raschzok 1 , Hannes Sallmon 2 , Christof Dame 2 , and Igor M. Sauer 1 1 General, Visceral, and Transplantation Surgery, Experimental Surgery and Regenerative Medicine, Campus Virchow Klinikum; and 2 Department of Neonatology, Charité-Universitätsmedizin Berlin, Berlin, Germany Address for reprint requests and other correspondence: N. Raschzok, General, Visceral, and Transplantation Surgery, Experimental Surgery and Regenerative Medicine, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany (e-mail: nathanael.raschzok@charite.de ). Submitted 28 November 2011. Accepted 21 December 2011. to the editor: Several recent studies investigated the role of microRNAs (miRNAs) in liver regeneration. These studies are typically based on microarray analyses of whole liver tissue, followed by quantitative real-time PCR or Northern blot confirmation. So far, nine studies have been published in this field ( 1 – 4 , 6 , 7 , 9 – 11 ), of which five studies ( 1 , 2 , 7 , 9 , 11 ) show a similar design in regard to the degree of partial hepatectomy (70%), species (rats), time points (2 h up to 5 days), and controls (sham laparotomy).
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Liver regeneration after partial hepatectomy: inconsistent results of expression screenings for human, mouse, and rat microRNAs
Raschzok, Nathanael; Sallmon, Hannes; Dame, Christof; Sauer, Igor M.
Follow AJP - Gastrointestinal and Liver Physiology
, Volume 302 (4): G470
The American Physiological Society – Feb 1, 2012
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