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Left ventricular function of the isolated, genetically obese rat's heart

Left ventricular function of the isolated, genetically obese rat's heart WARREN R. Ohio Universities College Medicine, Rootstown, Ohio 44272 NORMAN F., CHARLES F. WARREN R. JUDITH A. . functi the isolated, genetically obese rat’s . Am. J. Physiol. 248 ( Circ. Physiol. 17): H438-H444, 1985.-We sought to determine if (LV) functi the from the adult, chrically obese animal is impaired. s from 50 wk-old genetically obese female Zucker rats (624 t 13 g) their lean littermate ctrols (275 t 5 g) were isolated during ether anesthesia, supported metabolically by retrograde aortic perfusi (6 ml/min, 35°C) with physiological soluti ctaining suspended canine erythrocytes (hematocrit, 20%), the ventricles were paced at 180 beats/min. A distensible, fluidfilled ballo was placed in the LV, pressure- (PV) relatiships were obtained. The obese lean end-diastolic PV curves were not different, therefore the obese lean LV chamber compliances were similar. Comparis the systolic PV relatiships demstrated that the obese rat’s had a greater pressure-generating capability, which probably was a reflecti its increased LV mass (0.96 t 0.03 vs. 0.72 k 0.02 g). The calculated average meridial (or circumferential) peak systolic wall stress in the LV the obese rat’s , however, was significantly reduced compared with ctrol. This diminished ability to develop systolic stress from the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Left ventricular function of the isolated, genetically obese rat's heart

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Publisher
The American Physiological Society
Copyright
Copyright © 1985 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
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Abstract

WARREN R. Ohio Universities College Medicine, Rootstown, Ohio 44272 NORMAN F., CHARLES F. WARREN R. JUDITH A. . functi the isolated, genetically obese rat’s . Am. J. Physiol. 248 ( Circ. Physiol. 17): H438-H444, 1985.-We sought to determine if (LV) functi the from the adult, chrically obese animal is impaired. s from 50 wk-old genetically obese female Zucker rats (624 t 13 g) their lean littermate ctrols (275 t 5 g) were isolated during ether anesthesia, supported metabolically by retrograde aortic perfusi (6 ml/min, 35°C) with physiological soluti ctaining suspended canine erythrocytes (hematocrit, 20%), the ventricles were paced at 180 beats/min. A distensible, fluidfilled ballo was placed in the LV, pressure- (PV) relatiships were obtained. The obese lean end-diastolic PV curves were not different, therefore the obese lean LV chamber compliances were similar. Comparis the systolic PV relatiships demstrated that the obese rat’s had a greater pressure-generating capability, which probably was a reflecti its increased LV mass (0.96 t 0.03 vs. 0.72 k 0.02 g). The calculated average meridial (or circumferential) peak systolic wall stress in the LV the obese rat’s , however, was significantly reduced compared with ctrol. This diminished ability to develop systolic stress from the

Journal

AJP - Heart and Circulatory Physiology – The American Physiological Society

Published: Apr 1, 1985

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