SUSAN M. MAGDALENO,l GUIYING WANG,l KATHY J. JACKSON,l MANAS K. RAY,l STEVE WELTY,2 ROBERT H. COSTA,â AND FRANCESCO J. DEMAYO~ IDepartment Cell Biology and 2Department Pediatrics, Baylor College Medicine, Houston, Texas 77030; and 3Department Biochemistry, College Medicine, The University Illinois at Chicago, Chicago, Illinois 60612 Magdaleno, Susan M., Guiying Wang, Kathy J. Jackson, Manas K. Ray, Steve Welty, Robert H. Costa, and Francesco J. DeMayo. Interferon-y Clara cell gene : in vivo and in vitro. Am. J. PhysioZ. 272 (Lung Cell. Mol. Physiol. 16): Lll42-Lll51, 1997.-This report demonstrates that Clara cell lo-kDa protein (CClO) mRNA levels are regulated by interferon-y (IFN-y). An analysis total lung RNA from mice given intratracheally showed increased levels CC10 mRNA compared to control animals but no significant increases in surfactant proteins B and C. These results were confirmed in a Clara cell line, mtCCl-2, generated from the lungs a transgenic mouse expressing the SV40 large T antigen under the control a Clara cell-specific promoter. Significant increases in mtCCl2 CC10 mRNA levels were observed in a time- and a dose-dependent manner. The transacting factors hepatocyte nuclear factors 3a and 3p (HNF-3c~ and HNF-3P) were also analyzed, and a transient increase in the HNF-3l3 but
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Interferon-gamma regulation of Clara cell gene expression: in vivo and in vitro
S. M. Magdaleno , G. Wang , K. J. Jackson , M. K. Ray , S. Welty , R. H. Costa , and F. J. DeMayo
Follow AJP - Lung Cellular and Molecular Physiology
, Volume 272: L1142
The American Physiological Society – Jun 1, 1997
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