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SUPRIYA MARK A. CAROLYN AND RONALD CHRISTENSEN Division Endocrinology, Department Pediatrics, University Cincinnati Childrenâs Huspital Research Foundation, Cincinnati, Ohio 45229 SUPRIYA,MARK A. CAROLYN AND RONALD CHRTSTENSEN. glucagon-induced production by . Am. J. Physiol. 236(4): E358-E365, 1979 or Am. J. Physiol.: Endocrinol. Metab. Gastrointest. Physiol. 5(4): E358-E365, 1979.-We investigated the effects on plasma and insulin, (R,), and utilization (Rd) during constant glucagon infusion in intact, anesthetized postabsorptive rats. Glucagon infusion at 5 ng/( kg l rein) for 2 h achieved concentrations in plasma 375-580 pg/ml in all animals. In normal rats plasma rose from 114 t 3 mg/dl (mean t SE) to 134 t 4 mg/dl within 5 min (P < 0.01); values remained elevated for 90 min and then declined to basal by 120 min. Plasma insulin concentrations also increased transiently. R,, determined during infusion [Z-âHl, increased briefly after starting glucagon, but returned to basal by 15 min. had no effect on plasma , insulin, and glucagon concentrations or R, prior to or during a saline infusion. However, the same dose markedly attenuated the early plasma and insulin responses to glucagon (P < 0.05) and augmented the subsequent rate fall in and insulin so that values were significantly
AJP - Gastrointestinal and Liver Physiology – The American Physiological Society
Published: Apr 1, 1979
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