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Inhibition of glucagon-induced hepatic glucose production by indomethacin

Inhibition of glucagon-induced hepatic glucose production by indomethacin SUPRIYA MARK A. CAROLYN AND RONALD CHRISTENSEN Division Endocrinology, Department Pediatrics, University Cincinnati Children’s Huspital Research Foundation, Cincinnati, Ohio 45229 SUPRIYA,MARK A. CAROLYN AND RONALD CHRTSTENSEN. glucagon-induced production by . Am. J. Physiol. 236(4): E358-E365, 1979 or Am. J. Physiol.: Endocrinol. Metab. Gastrointest. Physiol. 5(4): E358-E365, 1979.-We investigated the effects on plasma and insulin, (R,), and utilization (Rd) during constant glucagon infusion in intact, anesthetized postabsorptive rats. Glucagon infusion at 5 ng/( kg l rein) for 2 h achieved concentrations in plasma 375-580 pg/ml in all animals. In normal rats plasma rose from 114 t 3 mg/dl (mean t SE) to 134 t 4 mg/dl within 5 min (P < 0.01); values remained elevated for 90 min and then declined to basal by 120 min. Plasma insulin concentrations also increased transiently. R,, determined during infusion [Z-“Hl, increased briefly after starting glucagon, but returned to basal by 15 min. had no effect on plasma , insulin, and glucagon concentrations or R, prior to or during a saline infusion. However, the same dose markedly attenuated the early plasma and insulin responses to glucagon (P < 0.05) and augmented the subsequent rate fall in and insulin so that values were significantly http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Gastrointestinal and Liver Physiology The American Physiological Society

Inhibition of glucagon-induced hepatic glucose production by indomethacin

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Publisher
The American Physiological Society
Copyright
Copyright © 1979 the American Physiological Society
ISSN
0193-1857
eISSN
1522-1547
Publisher site
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Abstract

SUPRIYA MARK A. CAROLYN AND RONALD CHRISTENSEN Division Endocrinology, Department Pediatrics, University Cincinnati Children’s Huspital Research Foundation, Cincinnati, Ohio 45229 SUPRIYA,MARK A. CAROLYN AND RONALD CHRTSTENSEN. glucagon-induced production by . Am. J. Physiol. 236(4): E358-E365, 1979 or Am. J. Physiol.: Endocrinol. Metab. Gastrointest. Physiol. 5(4): E358-E365, 1979.-We investigated the effects on plasma and insulin, (R,), and utilization (Rd) during constant glucagon infusion in intact, anesthetized postabsorptive rats. Glucagon infusion at 5 ng/( kg l rein) for 2 h achieved concentrations in plasma 375-580 pg/ml in all animals. In normal rats plasma rose from 114 t 3 mg/dl (mean t SE) to 134 t 4 mg/dl within 5 min (P < 0.01); values remained elevated for 90 min and then declined to basal by 120 min. Plasma insulin concentrations also increased transiently. R,, determined during infusion [Z-“Hl, increased briefly after starting glucagon, but returned to basal by 15 min. had no effect on plasma , insulin, and glucagon concentrations or R, prior to or during a saline infusion. However, the same dose markedly attenuated the early plasma and insulin responses to glucagon (P < 0.05) and augmented the subsequent rate fall in and insulin so that values were significantly

Journal

AJP - Gastrointestinal and Liver PhysiologyThe American Physiological Society

Published: Apr 1, 1979

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