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Journals Physiological Reviews Volume 92 Issue 1

Abstract Physiological processes are strictly organized in space and time. However, in cell physiology research, more attention is given to the question of space rather than to time. To function as a signal, environmental changes must be restricted in time; they need not only be initiated but also terminated. In this review, we concentrate on the role of one specific protein family involved in biological signal termination. GTPase activating proteins (GAPs) accelerate the endogenously low GTP hydrolysis rate of monomeric guanine nucleotide-binding proteins (GNBPs), limiting thereby their prevalence in the active, GTP-bound form. We discuss cases where defective or excessive GAP activity of specific proteins causes significant alteration in the function of the nervous, endocrine, and hemopoietic systems, or contributes to development of infections and tumors. Biochemical and genetic data as well as observations from human pathology support the notion that GAPs represent vital elements in the spatiotemporal fine tuning of physiological processes. « Previous | Next Article » Table of Contents This Article doi: 10.​1152/​physrev.​00045.​2010 Physiol Rev January 2012 vol. 92 no. 1 237-272 » Abstract Free Full Text Free to you Full Text (PDF) Free to you Classifications Article Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Ligeti, E. Articles by Scheffzek, K. PubMed Articles by Ligeti, E. Articles by Scheffzek, K. Related Content Load related web page information Current Issue January 2012, 92 (1) Alert me to new issues of Physiol Rev About the Journal Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2012 the American Physiological Society Print ISSN: 0031-9333 Online ISSN: 1522-1210 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview();

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Inhibition and Termination of Physiological Responses by GTPase Activating Proteins

Ligeti, Erzsébet; Welti, Stefan; Scheffzek, Klaus
Physiological Reviews , Volume 92 (1): 237
The American Physiological Society – Jan 1, 2012

More Info
  • Publisher American Physiological Society
  • Copyright Copyright © 2012 the American Physiological Society
  • ISSN 0031-9333
  • eISSN 1522-1210
  • D.O.I. 10.1152/physrev.00045.2010
  • Publisher site Get PDF  

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