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ethanol levels in rats with portacaval shunts. Am. J. Physiol. 248 (Gastrointest. Liver Physiol. 11): G2874292, 1985.~-In a seriesof experiments, it was demonstratedthat male rats with end-to-side portacaval shunts (PCS) consumedmore ethanol exhibited higher blood ethanol levels than sham-operated control animalsin chronic tests with 2% ethanol water ad libitum. Ethanol intake in the 6 h prior to blood samplingwas 2-5 times blood ethanol N-50 times higher in PCS than control rats. These effects were not due to the feminization of male rats occurring after a PCS, since female PCS rats exhibited comparableincreases ethanol intake blood ethanol. of In both sexes ethanol elimination rate alcohol dehydrogenaseactivity per total liver were lower after PCS than in control rats, explaining the disproportionate increasein blood ethanol relative to ethanol intake. Interestingly, ethanol intake wasnot abnormal in PCS rats fed a low-protein, low-tryptophan diet (corn) alone or as a supplementto the usual chow diet. Such dietary modulation of ethanol preference in this animal model of chronic liver dysfunction merits further attention. Eck fistula; alcohol dehydrogenase activity; ethanol elimination rate; preference test; sex comparison;low-protein, low-tryptophan diet we have observed that rats with a portacaval shunt (PCS) consumed much more ethanol than their sham-operated controls
AJP - Gastrointestinal and Liver Physiology – The American Physiological Society
Published: Mar 1, 1985
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