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Immunoreactive atriopeptin in plasma of fishes: its potential role in gill hemodynamics

Immunoreactive atriopeptin in plasma of fishes: its potential role in gill hemodynamics DAVID H., EVAN CHIPOURAS, AND JOHN A. PAYNE. Immunoreactive atriopeptin in plasma of fishes: its potential role in gill hemodynamics. Am. J. Physiol. 257 (Regulatory Integra- tive Comp. Physiol. 26): R939-R945, 1989.-With the use of antibodies raised against human atriopeptin (AP), immunoreactive AP (APi,) was quantified in the plasmaof five species of marine fishes, including membersof the Agnatha, Chondrichthyes, and Osteichthyes. Concentrations of APi, in fish plasmaare in the samerangeasthose describedfor mammalian species,indicating that AP was present in the earliest vertebrates and has retained at least partial structural similarity during the course of vertebrate evolution. Acclimation of two species very dilute seawaterwasassociated to with a significant reduction in plasma APi,, suggestingthat salt loading, rather than volume expansion, may be the primary stimulus for AP releasein fishes. Heterologous rat atriopeptin (APlOl-126) vasodilatedpreconstricted, perfusedgills and unstimulated isolated vascular rings from the ventral aorta of the marine teleost Opsanus beta with an apparent half maximum effective concentration (EC& of 3-4 X lo-’ M, similar to sensitivities to AP describedfor mammalianvascular smoothmuscle.Acclimation of toadfish to -5% seawater (hyposmotic to plasma) did not alter the sensitivity of the perfusedgills but reducedthe apparent EC& of rat AP on aortic rings to 3 x lo-” http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

Immunoreactive atriopeptin in plasma of fishes: its potential role in gill hemodynamics

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Publisher
The American Physiological Society
Copyright
Copyright © 1989 the American Physiological Society
ISSN
0363-6119
eISSN
1522-1490
Publisher site
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Abstract

DAVID H., EVAN CHIPOURAS, AND JOHN A. PAYNE. Immunoreactive atriopeptin in plasma of fishes: its potential role in gill hemodynamics. Am. J. Physiol. 257 (Regulatory Integra- tive Comp. Physiol. 26): R939-R945, 1989.-With the use of antibodies raised against human atriopeptin (AP), immunoreactive AP (APi,) was quantified in the plasmaof five species of marine fishes, including membersof the Agnatha, Chondrichthyes, and Osteichthyes. Concentrations of APi, in fish plasmaare in the samerangeasthose describedfor mammalian species,indicating that AP was present in the earliest vertebrates and has retained at least partial structural similarity during the course of vertebrate evolution. Acclimation of two species very dilute seawaterwasassociated to with a significant reduction in plasma APi,, suggestingthat salt loading, rather than volume expansion, may be the primary stimulus for AP releasein fishes. Heterologous rat atriopeptin (APlOl-126) vasodilatedpreconstricted, perfusedgills and unstimulated isolated vascular rings from the ventral aorta of the marine teleost Opsanus beta with an apparent half maximum effective concentration (EC& of 3-4 X lo-’ M, similar to sensitivities to AP describedfor mammalianvascular smoothmuscle.Acclimation of toadfish to -5% seawater (hyposmotic to plasma) did not alter the sensitivity of the perfusedgills but reducedthe apparent EC& of rat AP on aortic rings to 3 x lo-”

Journal

AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society

Published: Oct 1, 1989

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