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GRP-preferring bombesin receptors increase generation of inositol phosphates and tension in rat myometrium

GRP-preferring bombesin receptors increase generation of inositol phosphates and tension in rat... (Bn) structurally related naturally occurring peptides [gastrin-releasing peptide (GRP), neuromedin B (NMB), neuromedin C (NMC)] are widely distributed in mammals elicit multiple biological responses (24,28). Bn-related peptides may be of special interest as tumor markers growth factors in specific cell lines (22). They also contribute to the regulation of central nervous system functions such as thermoregulation (24), to the release of gastrointestinal hormones (24), to stimulation of pancreatic enzyme secretion (14), to the contraction of smooth muscles including the uterus (8, 21). Nerve fibers containing immunoreactive GRP-like material have been demonstrated in the rat uterus, raising the possibility that GRP (or a Bn-related peptide) may be one of several neural messengers involved in the control of the uterine motor activity (26). However, the mechanisms by which these peptides exert their effect on uterine contractility remained unclear. Specific plasma membrane for Bn-related peptides have been demonstrated in numerous tissues (9, 20, 22). Binding functional studies suggested that two classes of may mediate the action of Bn-related peptides (23, 30). One, the GRP-preferring receptor subtype, found in pancreatic tissue, had a high affinity for GRP Bn but a low affinity for NMB, whereas the other, the NMB-preferring receptor, found 0363-6143/93 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Cell Physiology The American Physiological Society

GRP-preferring bombesin receptors increase generation of inositol phosphates and tension in rat myometrium

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Publisher
The American Physiological Society
Copyright
Copyright © 1993 the American Physiological Society
ISSN
0363-6143
eISSN
1522-1563
Publisher site
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Abstract

(Bn) structurally related naturally occurring peptides [gastrin-releasing peptide (GRP), neuromedin B (NMB), neuromedin C (NMC)] are widely distributed in mammals elicit multiple biological responses (24,28). Bn-related peptides may be of special interest as tumor markers growth factors in specific cell lines (22). They also contribute to the regulation of central nervous system functions such as thermoregulation (24), to the release of gastrointestinal hormones (24), to stimulation of pancreatic enzyme secretion (14), to the contraction of smooth muscles including the uterus (8, 21). Nerve fibers containing immunoreactive GRP-like material have been demonstrated in the rat uterus, raising the possibility that GRP (or a Bn-related peptide) may be one of several neural messengers involved in the control of the uterine motor activity (26). However, the mechanisms by which these peptides exert their effect on uterine contractility remained unclear. Specific plasma membrane for Bn-related peptides have been demonstrated in numerous tissues (9, 20, 22). Binding functional studies suggested that two classes of may mediate the action of Bn-related peptides (23, 30). One, the GRP-preferring receptor subtype, found in pancreatic tissue, had a high affinity for GRP Bn but a low affinity for NMB, whereas the other, the NMB-preferring receptor, found 0363-6143/93

Journal

AJP - Cell Physiology – The American Physiological Society

Published: Dec 1, 1993

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