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NANCY S. KRIEGER of Rochester, Rochester, New York 14642 31): F425-F431, 1992.-There is a smaller net from bone in vitro during respiratory (increasedPco,) than metabolic (decreased [HCO;]) . This could be due to the elevated lko2, which would lessenthe driving force for mineral dissolution and increasethe driving force for mineralization respect to carbonatedapatite in the bone mineral. To test this hypothesis, we injected neonatal mice 45Caand dissectedthe radiolabeledcalvariae 24 h later. The live calvariae were then cultured for 24 h under conditions simulating respiratory (Resp,pH = 7.225 t 0.003, PCO~ = 87.5 t 0.1 ), severe respiratory (SResp, pH = 7.072 k 0.004, PCO* = 103.0 t 0.5 ), metabolic (Met, pH = 7.212 k 0.003, HCO, = 15.5 t 0.1 meq/l), or normal acid-basestatus (Ctl, pH = 7.452t 0.003, PCO~ = 40.0 t 0.2 , HCO; = 27.8 t 0.2 meq/l) and bidirectional net flux (JcJ and 4âCareleasewere determined. There wasgreater Jca from bone during Met than Resp,and Jca wasnot different from Met during SRespdespitethe latter having a significantly lower pH. There was greater 4âCa releasefrom bone during Met than Resp,SResp,or Ctl. There wasa similar direct correlation betweenJca and 4âCa in the respiratory and metabolic groups. However,
AJP - Renal Physiology – The American Physiological Society
Published: Mar 1, 1992
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