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Fructose-1,6-bisphosphate improves efficiency of work in isolated perfused rat hearts

Fructose-1,6-bisphosphate improves efficiency of work in isolated perfused rat hearts JOSEPH W. STARNES, K. STEPHEN SEILER, DOUGLAS K. BOWLES, BRUNO GIARDINA, AND GIUSEPPE LAZZARINO Department Kinesiology, The University Texas at Austin, Austin, TX 78712; and Department Experimental Medicine and Biochemical Sciences, II University Rome, 00173 Rome, Italy Starnes, Joseph W., K. Stephen Seiler, Douglas K. Bowles, Bruno Giardina, and Giuseppe Lazzarino. Fructose-1,6-bisphosphate improves efficiency work in isolated perfused rat hearts. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H380-H384, 1992.-The purpose this study was to determine whether exogenous fructose-1,6-bisphosphate (F1,6-P2) directly affects hemodynamics and certain metabolic parameters. Isolated working rat hearts were perfused for 30 min with 10 mM glucose (+insulin) as the exclusive exogenous substrate followed by 15 min with glucose plus e the following ccentratis (in mM) F-1,6-Pz: 1.25, 2.5, 5, or 10, and finally returned to the glucose ly buffer. Additis 2.5 and 5 mM F-1,6-P2 decreased (P < 0.01) oxygen csumpti (vo2) by 10.8 and 17.0% and corary flow by 8.3 and 10.3%, respectively. No changes were observed in lactate release, cardiac output (CO), peak systolic pressure, heart rate, or pressure work (PW). Efficiency, expressed as PW divided by Vo2, increased with F-1,6-Pz by 8.6% with 1.25 mM (P < 0.05), 13.2% with 2.5 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Fructose-1,6-bisphosphate improves efficiency of work in isolated perfused rat hearts

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Publisher
The American Physiological Society
Copyright
Copyright © 1992 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
See Article on Publisher Site

Abstract

JOSEPH W. STARNES, K. STEPHEN SEILER, DOUGLAS K. BOWLES, BRUNO GIARDINA, AND GIUSEPPE LAZZARINO Department Kinesiology, The University Texas at Austin, Austin, TX 78712; and Department Experimental Medicine and Biochemical Sciences, II University Rome, 00173 Rome, Italy Starnes, Joseph W., K. Stephen Seiler, Douglas K. Bowles, Bruno Giardina, and Giuseppe Lazzarino. Fructose-1,6-bisphosphate improves efficiency work in isolated perfused rat hearts. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H380-H384, 1992.-The purpose this study was to determine whether exogenous fructose-1,6-bisphosphate (F1,6-P2) directly affects hemodynamics and certain metabolic parameters. Isolated working rat hearts were perfused for 30 min with 10 mM glucose (+insulin) as the exclusive exogenous substrate followed by 15 min with glucose plus e the following ccentratis (in mM) F-1,6-Pz: 1.25, 2.5, 5, or 10, and finally returned to the glucose ly buffer. Additis 2.5 and 5 mM F-1,6-P2 decreased (P < 0.01) oxygen csumpti (vo2) by 10.8 and 17.0% and corary flow by 8.3 and 10.3%, respectively. No changes were observed in lactate release, cardiac output (CO), peak systolic pressure, heart rate, or pressure work (PW). Efficiency, expressed as PW divided by Vo2, increased with F-1,6-Pz by 8.6% with 1.25 mM (P < 0.05), 13.2% with 2.5

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: Feb 1, 1992

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