Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
JOSEPH W. STARNES, K. STEPHEN SEILER, DOUGLAS K. BOWLES, BRUNO GIARDINA, AND GIUSEPPE LAZZARINO Department Kinesiology, The University Texas at Austin, Austin, TX 78712; and Department Experimental Medicine and Biochemical Sciences, II University Rome, 00173 Rome, Italy Starnes, Joseph W., K. Stephen Seiler, Douglas K. Bowles, Bruno Giardina, and Giuseppe Lazzarino. Fructose-1,6-bisphosphate improves efficiency work in isolated perfused rat hearts. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H380-H384, 1992.-The purpose this study was to determine whether exogenous fructose-1,6-bisphosphate (F1,6-P2) directly affects hemodynamics and certain metabolic parameters. Isolated working rat hearts were perfused for 30 min with 10 mM glucose (+insulin) as the exclusive exogenous substrate followed by 15 min with glucose plus e the following ccentratis (in mM) F-1,6-Pz: 1.25, 2.5, 5, or 10, and finally returned to the glucose ly buffer. Additis 2.5 and 5 mM F-1,6-P2 decreased (P < 0.01) oxygen csumpti (vo2) by 10.8 and 17.0% and corary flow by 8.3 and 10.3%, respectively. No changes were observed in lactate release, cardiac output (CO), peak systolic pressure, heart rate, or pressure work (PW). Efficiency, expressed as PW divided by Vo2, increased with F-1,6-Pz by 8.6% with 1.25 mM (P < 0.05), 13.2% with 2.5
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Feb 1, 1992
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.