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and human AK10 MORIMOTO, AND NAOTOSHI YOSHIYUKI MURAKAMI SAKATA, of Physiology, Yamaguchi University School of Medicine, Ube, Yamaguchi 755, Japan Yamashiro, Osamu, Akio Morimoto, Yoshiyuki Sakata, Tatsuo Watanabe, and Naotoshi Murakami. Febrile and metabolic to endotoxin and human recombinant interleukin-lp in rabbits. Am. J. Physiol. 264 (Regulatory Integrative Comp. Physiol. 33): Rll80-Rl185, 1993.-We investigated whether or not of the febrile and metabolic responses human recombinant interleukin- l@ (IL- lp) to developsin rabbits. Febrile to bacterial endotoxin was by daily injections of lipopolysaccharide (LPS, 5.0 pg/kg iv). In LPS-t o1 erant rabbits, the second phase of the biphasic fever by intravenous injections of LPS (5.0 pg/kg) or IL-lb (2.0 pg/k g) wassignificantly reduced.However, the first phasewasalmost the sameas that observedin normal rabbits. Five daily injections of IL-lb (2.0 pg/kg iv) resultedin the developmentof of the febrile response IL-l& In to IL-lfl-tolerant rabbits, the secondpeak of the biphasic fever was significantly reduced. In addition, decreases leukocyte in count and plasmazinc by intravenous injections of LPS or IL-l/3 were significantly reducedin LPS- or IL-I@-tolerant rabbits. However the monophasic fever by a smallerdose of IL-lp (0.5 pg/kg iv) and the first peak of the IL-l biphasic fever were almostthe sameasthose observedin normal
AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society
Published: Jun 1, 1993
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