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Journals Physiological Reviews Volume 92 Issue 1

Abstract The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy conditions, they limit the excitability of spinal terminals of primary sensory nerve fibers and of intrinsic dorsal horn neurons through pre- and postsynaptic mechanisms, and thereby facilitate the spatial and temporal discrimination of sensory stimuli. Removal of fast inhibition not only reduces the fidelity of normal sensory processing but also provokes symptoms very much reminiscent of pathological and chronic pain syndromes. This review summarizes our knowledge of the molecular bases of spinal inhibitory neurotransmission and its organization in dorsal horn sensory circuits. Particular emphasis is placed on the role and mechanisms of spinal inhibitory malfunction in inflammatory and neuropathic chronic pain syndromes. « Previous | Next Article » Table of Contents This Article doi: 10.​1152/​physrev.​00043.​2010 Physiol Rev January 2012 vol. 92 no. 1 193-235 » Abstract Free Full Text Free to you Full Text (PDF) Free to you Classifications Article Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Zeilhofer, H. U. Articles by Yévenes, G. E. PubMed Articles by Zeilhofer, H. U. Articles by Yévenes, G. E. Related Content Load related web page information Current Issue January 2012, 92 (1) Alert me to new issues of Physiol Rev About the Journal Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2012 the American Physiological Society Print ISSN: 0031-9333 Online ISSN: 1522-1210 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview();

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Fast Synaptic Inhibition in Spinal Sensory Processing and Pain Control

Zeilhofer, Hanns Ulrich; Wildner, Hendrik; Yévenes, Gonzalo E.
Physiological Reviews , Volume 92 (1): 193
The American Physiological Society – Jan 1, 2012

More Info
  • Publisher American Physiological Society
  • Copyright Copyright © 2012 the American Physiological Society
  • ISSN 0031-9333
  • eISSN 1522-1210
  • D.O.I. 10.1152/physrev.00043.2010
  • Publisher site Get PDF  

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