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Extrapancreatic effect of somatostatin infusion to increase glucose clearance

Extrapancreatic effect of somatostatin infusion to increase glucose clearance T. FINEof infusion to increase glucose . Am, J. Physiol. 247 (Endocrinol. Metab. 10): E37043379, 1984.-Constant intraportal insulin, coupled variable intraportal glucagon, was used in the attempt to reestablish basal metabolic conditions in dogs during (SRIF) infusion (0.8 pg. min-l kg-l). SRIF alone lowered glucose (G), insulin (I) 9 and glucagon (GN) (G: 90 + 5 to 69 t 1 mg/dl; I: 18 t 4 to 4 3- 1 &J/ml; GN: 257 & 52 to 168 & 40 pg/ml; p < 0.05 or better). Hormone replacement. Hypoglycemia persisted (G at steady state, SS, 60-150 min): 12 -+ 3 mg/dl below basal; P = 0.006) despite intraportal insulin replacement (ZOO pU* min-l kg?; insulin at basal: 14 t 1; at SS: 14 * 2 pU/ml; p > 0.9) and glucagon overreplacement (basal: 341 $- 42; SS: 486 t 80 pg/ ml; P < 0.05). Glucose was incieased 65% above basal (P 4 0.0001). Insulin underreplacement. a lower intraportal insulin infusion rate (50 pug min-l kg-l), insulin fell from basal (10 t 2 pU/ml) to 4 t 1 pU/ml during steady state (P = 0.03). Glucose and glucose were normalized to basal values (G: 85 t 3 mg/dl, P = http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Extrapancreatic effect of somatostatin infusion to increase glucose clearance

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Publisher
The American Physiological Society
Copyright
Copyright © 1984 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
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Abstract

T. FINEof infusion to increase glucose . Am, J. Physiol. 247 (Endocrinol. Metab. 10): E37043379, 1984.-Constant intraportal insulin, coupled variable intraportal glucagon, was used in the attempt to reestablish basal metabolic conditions in dogs during (SRIF) infusion (0.8 pg. min-l kg-l). SRIF alone lowered glucose (G), insulin (I) 9 and glucagon (GN) (G: 90 + 5 to 69 t 1 mg/dl; I: 18 t 4 to 4 3- 1 &J/ml; GN: 257 & 52 to 168 & 40 pg/ml; p < 0.05 or better). Hormone replacement. Hypoglycemia persisted (G at steady state, SS, 60-150 min): 12 -+ 3 mg/dl below basal; P = 0.006) despite intraportal insulin replacement (ZOO pU* min-l kg?; insulin at basal: 14 t 1; at SS: 14 * 2 pU/ml; p > 0.9) and glucagon overreplacement (basal: 341 $- 42; SS: 486 t 80 pg/ ml; P < 0.05). Glucose was incieased 65% above basal (P 4 0.0001). Insulin underreplacement. a lower intraportal insulin infusion rate (50 pug min-l kg-l), insulin fell from basal (10 t 2 pU/ml) to 4 t 1 pU/ml during steady state (P = 0.03). Glucose and glucose were normalized to basal values (G: 85 t 3 mg/dl, P =

Journal

AJP - Endocrinology and Metabolism – The American Physiological Society

Published: Sep 1, 1984

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