Abstract Differences in feed intake and production efficiency in lactating Holstein-Friesian (HF), Jersey (JE), and JE × HF (F 1 ) dairy cows have been reported. The liver-gut axis is important in the regulation of energy homeostasis, appetite behaviour, and production efficiency. The objectives of this study were to determine: 1 ) the effect of dairy cow genotype on the expression profiles of genes involved in energy homeostasis in duodenal and hepatic tissue, and 2 ) the association between the expression of these genes across both tissues and with economically important production efficiency traits. The expression of 27 candidate genes involved in energy homeostasis, feed intake, and energy storage was measured by qPCR. Duodenal expression of the pro-opiomelanocortin ( POMC ), glucagon-like peptide 1 receptor ( GLP1R ), and insulin-like growth factor 1 ( IGF1 ) genes was highest in HF. In contrast, hepatic expression of the leptin receptor ( LEPR ), insulin-like growth factor 1 receptor ( IGF1R ), protein kinase, AMP-activated, beta 1 ( AMPKB1 ), and POMC genes was highest in the F 1 cross. In the duodenum, positive correlations were observed between mRNA expression of anorectic peptides ( POMC and GLP1R ), whereas a negative correlation was detected between orexigenic (ghrelin) and anorectic (peptide YY) gene expression. A negative correlation was observed between duodenal POMC gene expression and both residual feed intake and milk production efficiency traits, while GLP1R gene expression was negatively correlated with milk production efficiency traits. A heterotic effect was observed in hepatic expression of AMKPB1 , IGF1R , LEPR , POMC in the F 1 genotype, possibly mediating improved feed efficiency in cross-bred cows. In conclusion, key genes involved in energy homeostasis and appetite behaviour are differentially expressed due to cow genotype in a tissue-dependent fashion. POMC and GLP1R are potential candidate genes for the identification of single nucleotide polymorphisms regulating energetic efficiency in the dairy cow, which may be incorporated into future breeding programmes. gene expression cattle genotypes absorption nutrients Copyright © 2012 the American Physiological Society « Previous Table of Contents This Article Published online before print December 2011 , doi: 10.​1152/​physiolgenomics.​00102.​2011 Physiol. Genomics January 2012 vol. 44 no. 2 198-209 » Abstract Free Full Text Free to you Full Text (PDF) Free to you All Versions of this Article: physiolgenomics.00102.2011v1 44/2/198 most recent Classifications Research Article Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Alam, T. Articles by Waters, S. M. PubMed PubMed citation Articles by Alam, T. Articles by Waters, S. M. Related Content Load related web page information Current Issue January 2012, 44 (2) Alert me to new issues of Physiol. Genomics About the Journal Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2012 the American Physiological Society Print ISSN: 1094-8341 Online ISSN: 1531-2267 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview();

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