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Exercise prevents Western diet-associated erectile dysfunction and coronary artery endothelial dysfunction: response to acute apocynin and sepiapterin treatment

Exercise prevents Western diet-associated erectile dysfunction and coronary artery endothelial... REFERENCES 1. ↵ Adams V , Linke A , Krankel N , Erbs S , Gielen S , Möbius-Winkler S , Gummert JF , Mohr FW , Schuler G , Hambrecht R . Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease . Circulation 111 : 555 – 562 , 2005 . OpenUrl Abstract / FREE Full Text 2. ↵ Alp NJ , Channon KM . Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease . Arterioscler Thromb Vasc Biol 24 : 413 – 420 , 2004 . OpenUrl Abstract / FREE Full Text 3. ↵ Anderson EJ , Yamazaki H , Neufer PD . Induction of endogenous uncoupling protein 3 suppresses mitochondrial oxidant emission during fatty acid-supported respiration . J Biol Chem 282 : 31257 – 31266 , 2007 . OpenUrl Abstract / FREE Full Text 4. ↵ Angulo J , Peiró C , Cuevas P , Gabancho S , Fernández A , González-Corrochano R , La Fuente JM , Baron AD , Chen KS , Saenz de Tejada I . The novel antioxidant, AC3056 (2,6-di-t-butyl-4-((dimethyl-4-methoxyphenylsilyl) methyloxy) phenol), reverses erectile dysfunction in diabetic rats and improves NO-mediated responses in penile tissue from diabetic men . J Sex Med 6 : 373 – 387 , 2009 . OpenUrl CrossRef Medline 5. ↵ Ayta IA , McKinlay JB , Krane RJ . The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences . BJU Int 84 : 50 – 56 , 1999 . OpenUrl CrossRef Medline Web of Science 6. ↵ Bergholm R , Mäkimattila S , Valkonen M , Liu ML , Lahdenperä S , Taskinen MR , Sovijärvi A , Malmberg P , Yki-Järvinen H . Intense physical training decreases circulating antioxidants and endothelium-dependent vasodilation in vivo . Atherosclerosis 145 : 341 – 349 , 1999 . OpenUrl CrossRef Medline Web of Science 7. ↵ Bivalacqua TJ , Usta MF , Kendirci M , Pradhan L , Alvarez X , Champion HC , Kadowitz PJ , Hellstrom WJG . Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy . J Sex Med 2 : 187 – 198 , 2005 . OpenUrl CrossRef Medline Web of Science 8. ↵ Borgquist R , Gudmundsson P , Winter R , Nilsson P , Willenheimer R . Erectile dysfunction in healthy subjects predicts reduced coronary flow velocity reserve . Int J Cardiol 112 : 166 – 170 , 2006 . OpenUrl CrossRef Medline Web of Science 9. ↵ Cai H , Harrison DG . Endothelial dysfunction in cardiovascular disease: the role of oxidant stress . Circ Res 87 : 840 – 844 , 2000 . OpenUrl Abstract / FREE Full Text 10. ↵ Castor LR , Locatelli KA , Ximenes VF . Pro-oxidant activity of apocynin radical . Free Radic Biol Med 48 : 1636 – 1643 , 2010 . OpenUrl CrossRef Medline 11. ↵ Channon KM . Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease . Trends Cardiovasc Med 14 : 323 – 327 , 2004 . OpenUrl CrossRef Medline Web of Science 12. ↵ de Moraes C , Davel AP , Rossoni LV , Antunes E , Zanesco A . Exercise training improves relaxation response and SOD-1 expression in aortic and mesenteric rings from high caloric diet-fed rats . BMC Physiol 8 : 12 , 2008 . OpenUrl CrossRef Medline 13. ↵ Derby CA , Mohr BA , Goldstein I , Feldman HA , Johannes CB , McKinlay JB . Modifiable risk factors and erectile dysfunction: can lifestyle changes modify risk? Urology 56 : 302 – 306 , 2000 . OpenUrl CrossRef Medline Web of Science 14. ↵ Esposito K , Giugliano D . Obesity, the metabolic syndrome, and sexual dysfunction . Int J Impot Res 17 : 391 – 398 , 2005 . OpenUrl CrossRef Medline Web of Science 15. ↵ Esposito K , Giugliano F , Di Palo C , Giugliano G , Marfella R , D'Andrea F , D'Armiento M , Giugliano D . Effect of lifestyle changes on erectile dysfunction in obese men . JAMA 291 : 2978 – 2984 , 2004 . OpenUrl CrossRef Medline Web of Science 16. ↵ Finucane MM , Stevens GA , Cowan MJ , Danaei G , Lin JK , Paciorek CJ , Singh GM , Gutierrez HR , Lu Y , Bahalim AN , Farzadfar F , Riley LM , Ezzati M . Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index). National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants . Lancet 377 : 557 – 567 , 2011 . OpenUrl CrossRef Medline Web of Science 17. ↵ Fisher-Wellman KH , Mattox TA , Thayne K , Katunga LA , La Favor JD , Neufer PD , Hickner RC , Wingard CJ , Anderson EJ . Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle . J Physiol In press . 18. ↵ Frasier CR , Moukdar F , Patel HD , Sloan RC , Stewart LM , Alleman RJ , La Favor JD , Brown DA . Redox-dependent increases in glutathione reductase and exercise preconditioning: role of NADPH oxidase and mitochondria . Cardiovasc Res 98 : 47 – 55 , 2013 . OpenUrl Abstract / FREE Full Text 19. ↵ Galili O , Versari D , Sattler KJ , Olson ML , Mannheim D , McConnell JP , Chade AR , Lerman LO , Lerman A . Early experimental obesity is associated with coronary endothelial dysfunction and oxidative stress . Am J Physiol Heart Circ Physiol 292 : H904 – H911 , 2007 . OpenUrl Abstract / FREE Full Text 20. ↵ Gao X , Belmadani S , Picchi A , Xu X , Potter BJ , Tewari-Singh N , Capobianco S , Chilian WM , Zhang C . Tumor necrosis factor-alpha induces endothelial dysfunction in Lepr(db) mice . Circulation 115 : 245 – 254 , 2007 . OpenUrl Abstract / FREE Full Text 21. ↵ Glina S , Sharlip ID , Hellstrom WJ . Modifying risk factors to prevent and treat erectile dysfunction . J Sex Med 10 : 115 – 119 , 2012 . OpenUrl Medline 22. ↵ Guzik TJ , Mussa S , Gastaldi D , Sadowski J , Ratnatunga C , Pillai R , Channon KM . Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase . Circulation 105 : 1656 – 1662 , 2002 . OpenUrl Abstract / FREE Full Text 23. ↵ Guzik TJ , Sadowski J , Guzik B , Jopek A , Kapelak B , Przybylowski P , Wierzbicki K , Korbut R , Harrison DG , Channon KM . Coronary artery superoxide production and Nox isoform expression in human coronary artery disease . Arterioscler Thromb Vasc Biol 26 : 333 – 339 , 2006 . OpenUrl Abstract / FREE Full Text 24. ↵ Hannan JL , Maio MT , Komolova M , Adams MA . Beneficial impact of exercise and obesity interventions on erectile function and its risk factors . J Sex Med 6 Suppl 3 : 254 – 261 , 2009 . OpenUrl CrossRef Medline 25. ↵ Haram PM , Adams V , Kemi OJ , Brubakk AO , Hambrecht R , Ellingsen Ø , Wisløff U . Time-course of endothelial adaptation following acute and regular exercise . Eur J Cardiovasc Prev Rehabil 13 : 585 – 591 , 2006 . OpenUrl CrossRef Medline Web of Science 26. ↵ Haram PM , Kemi OJ , Lee SJ , Bendheim MØ , Al-Share QY , Waldum HL , Gilligan LJ , Koch LG , Britton SL , Najjar SM , Wisløff U . Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity . Cardiovasc Res 81 : 723 – 732 , 2009 . OpenUrl Abstract / FREE Full Text 27. ↵ Heumüller S , Wind S , Barbosa-Sicard E , Schmidt HH , Busse R , Schröder K , Brandes RP . Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant . Hypertension 51 : 211 – 217 , 2008 . OpenUrl CrossRef 28. ↵ Høydal MA , Wisløff U , Kemi OJ , Ellingsen O . Running speed and maximal oxygen uptake in rats and mice: practical implications for exercise training . Eur J Cardiovasc Prev Rehabil 14 : 753 – 760 , 2007 . OpenUrl CrossRef Medline Web of Science 29. ↵ Hsiao W , Shrewsberry AB , Moses KA , Johnson TV , Cai AW , Stuhldreher P , Dusseault B , Ritenour CWM . Exercise is associated with better erectile function in men under 40 as evaluated by the international index of erectile function . J Sex Med 9 : 524 – 530 , 2012 . OpenUrl CrossRef Medline 30. ↵ Jackson G , Montorsi P , Adams MA , Anis T , El-Sakka A , Miner M , Vlachopoulos C , Kim E . Cardiovascular aspects of sexual medicine . J Sex Med 7 : 1608 – 1626 , 2010 . OpenUrl CrossRef Medline 31. ↵ Jackson G , Padley S . Erectile dysfunction and silent coronary artery disease: abnormal computed tomography coronary angiogram in the presence of normal exercise ECGs . Int J Clin Pract 62 : 973 – 976 , 2008 . 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OpenUrl Abstract / FREE Full Text 36. ↵ La Favor JD , Anderson EJ , Hickner RC , Wingard CJ . Erectile dysfunction precedes coronary artery endothelial dysfunction in rats fed a high-fat, high-sucrose, Western pattern diet . J Sex Med 10 : 694 – 703 , 2013 . OpenUrl CrossRef Medline 37. ↵ Laursen JB , Somers M , Kurz S , McCann L , Warnholtz A , Freeman BA , Tarpey M , Fukai T , Harrison DG . Endothelial regulation of vasomotion in ApoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin . Circulation 103 : 1282 – 1288 , 2001 . OpenUrl Abstract / FREE Full Text 38. ↵ Long T , Liu G , Wang Y , Chen Y , Zhang Y , Qin D . TNF-α, erectile dysfunction, and NADPH oxidase-mediated ROS generation in corpus cavernosum in high-fat diet/streptozotocin-induced diabetic rats . J Sex Med 9 : 1801 – 1814 , 2012 . OpenUrl CrossRef Medline 39. ↵ Meldrum DR , Gambone JC , Morris MA , Esposito K , Giugliano D , Ignarro LJ . Lifestyle and metabolic approaches to maximizing erectile and vascular health . Int J Impot Res 24 : 61 – 68 , 2012 . OpenUrl CrossRef Medline 40. ↵ Montorsi F , Briganti A , Salonia A , Rigatti P , Margonato A , Macchi A , Galli S , Ravagnani PM , Montorsi P . Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease . Eur Urol 44 : 360 – 364 , 2003 . OpenUrl CrossRef Medline Web of Science 41. ↵ Munk PS , Staal EM , Butt N , Isaksen K , Larsen AI . High-intensity interval training may reduce in-stent restenosis following percutaneous coronary intervention with stent implantation: a randomized controlled trial evaluating the relationship to endothelial function and inflammation . Am Heart J 158 : 734 – 741 , 2009 . OpenUrl CrossRef Medline Web of Science 42. ↵ Musicki B , Liu T , Lagoda GA , Strong TD , Sezen SF , Johnson JM , Burnett AL . Hypercholesterolemia-induced erectile dysfunction: endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidase . J Sex Med 7 : 3023 – 3032 , 2010 . OpenUrl CrossRef Medline 43. ↵ Musicki B , Liu T , Strong T , Jin L , Laughlin MH , Turk JR , Burnett AL . Low-fat diet and exercise preserve eNOS regulation and endothelial function in the penis of early atherosclerotic pigs: a molecular analysis . J Sex Med 5 : 552 – 561 , 2008 . OpenUrl CrossRef Medline 44. ↵ Park Y , Booth FW , Lee S , Laye MJ , Zhang C . Physical activity opposes coronary vascular dysfunction induced during high fat feeding in mice . J Physiol 590 : 4255 – 4268 , 2012 . OpenUrl Abstract / FREE Full Text 45. ↵ Picchi A , Gao X , Belmadani S , Potter BJ , Focardi M , Chilian WM , Zhang C . Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome . Circ Res 99 : 69 – 77 , 2006 . OpenUrl Abstract / FREE Full Text 46. ↵ Popkin BM , Adair LS , Ng SW . 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OpenUrl Abstract / FREE Full Text 50. ↵ Shukla N , Jones R , Persad R , Angelini GD , Jeremy JY . Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits . Eur J Pharmacol 517 : 224 – 231 , 2005 . OpenUrl CrossRef Medline Web of Science 51. ↵ Stolk J , Hiltermann TJ , Dijkman JH , Verhoeven AJ . Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol . Am J Respir Cell Mol Biol 11 : 95 – 102 , 1994 . OpenUrl Medline Web of Science 52. ↵ Sun MW , Zhong MF , Gu J , Qian FL , Gu JZ , Chen H . Effects of different levels of exercise volume on endothelium-dependent vasodilation: roles of nitric oxide synthase and heme oxygenase . Hypertens Res 31 : 805 – 816 , 2008 . OpenUrl CrossRef Medline 53. ↵ Suresh S , Prakash S . Effect of Mucuana pruriens (Linn.) on oxidative stress-induced structural alteration of corpus cavernosum in streptozotocin-induced diabetic rat . J Sex Med 8 : 1943 – 1956 , 2011 . OpenUrl CrossRef Medline 54. ↵ Thompson IM , Tangen CM , Goodman PJ , Probstfield JL , Moinpoiur CM , Coltman CA . Erectile dysfunction and subsequent cardiovascular disease . JAMA 294 : 2996 – 3002 , 2005 . OpenUrl CrossRef Medline Web of Science 55. ↵ Thompson MA , Henderson KK , Woodman CR , Turk JR , Rush JW , Price E , Laughlin MH . Exercise preserves endothelium-dependent relaxation in coronary arteries of hypercholesterolemic male pigs . J Appl Physiol 96 : 1114 – 1126 , 2004 . OpenUrl Abstract / FREE Full Text 56. ↵ Tjønna AE , Lee SJ , Rognmo Ø , Stolen TO , Bye A , Haram PM , Loennechen JP , Al-Share QY , Skogvoll E , Slørdahl AT , Kemi OJ , Najjar SM , Wisløff U . Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study . Circulation 118 : 346 – 354 , 2008 . OpenUrl Abstract / FREE Full Text 57. ↵ Tsutsui M , Milstien S , Katusic ZS . Effect of tetrahydrobiopterin on endothelial function in canine middle cerebral arteries . Circ Res 79 : 336 – 342 , 1996 . OpenUrl Abstract / FREE Full Text 58. ↵ Vásquez-Vivar J , Duquaine D , Whitsett J , Kalyanaraman B , Rajagopalan S . Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants . Arterioscler Thromb Vasc Biol 22 : 1655 – 1661 , 2002 . OpenUrl Abstract / FREE Full Text 59. ↵ Vásquez-Vivar J , Martasek P , Whitsett J , Joseph J , Kalyanaraman B . The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study . Biochem J 362 : 733 – 739 , 2002 . OpenUrl CrossRef Medline Web of Science 60. ↵ Vlachopoulos C , Jackson G , Stefanadis C , Montorsi P . Erectile dysfunction in the cardiovascular patient . Eur Heart J In press . 61. ↵ Vlachopoulos CV , Terentes-Printzios DG , Ioakeimidis NK , Aznaouridis KA , Stefanadis CI . Prediction of cardiovascular events and all-cause mortality with erectile dysfunction: a systemic review and meta-analysis of cohort studies . Circ Cardiovasc Qual Outcomes 6 : 99 – 109 , 2013 . OpenUrl Abstract / FREE Full Text 62. ↵ Vladic N , Ge ZD , Leucker T , Brzezinska AK , Du JH , Shi Y , Warltier DC , Pratt PF Jr . , Kersten JR . Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning . Am J Physiol Heart Circ Physiol 301 : H2130 – H2139 , 2011 . OpenUrl Abstract / FREE Full Text 63. ↵ Widlansky ME , Gutterman DD . Regulation of endothelial function by mitochondrial reactive oxygen species . Antioxid Redox Signal 15 : 1517 – 1530 , 2011 . OpenUrl CrossRef Medline Web of Science 64. ↵ Wingard C , Fulton D , Husain S . Altered penile vascular reactivity and erection in the Zucker obese-diabetic rat . J Sex Med 4 : 348 – 363 , 2007 . OpenUrl CrossRef Medline Web of Science 65. ↵ Wisløff U , Helgerud J , Kemi OJ , Ellingsen O . Intensity-controlled treadmill running in rats: V̇ o 2max and cardiac hypertrophy . Am J Physiol Heart Circ Physiol 280 : H1301 – H1310 , 2001 . OpenUrl Abstract / FREE Full Text 66. ↵ Wisløff U , Støylen A , Loennechen JP , Bruvold M , Rognmo Ø , Haram PM , Tjønna AE , Helgerud J , Slørdahl SA , Lee SJ , Videm V , Bye A , Smith GL , Najjar SM , Ellingsen Ø , Skjaerpe T . Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study . Circulation 115 : 3086 – 3094 , 2007 . OpenUrl Abstract / FREE Full Text 67. ↵ Yamashita N , Hoshida S , Otsu K , Asahi M , Kuzuya T , Hori M . Exercise provides direct biphasic cardioprotection via manganese superoxide dismutase activation . J Exp Med 189 : 1699 – 1706 , 1999 . OpenUrl Abstract / FREE Full Text Previous Next Back to top About the Cover About the Cover Cover image Image 1: Scully CG, Mitrou N, Braam B, Cupples WA, Chon KH. Detecting physiological systems with laser speckle perfusion imaging of the renal cortex . Am J Physiol Regul Integr Comp Physiol ; published ahead of print April 3, 2013, doi:10.1152/ajpregu.00002.2013. Image 2: Roy A, Derakhshan F, Wilson RJ. PACAP engages multiple signaling pathways within the carotid body to initiate excitatory responses in respiratory and sympathetic chemosensory afferents . Am J Physiol Regul Integr Comp Physiol ; published ahead of print April 17, 2013, doi:10.1152/ajpregu.00465.2012. Image 3: Shih T, Horng J, Lai Y, Lin L. Rhcg1 and Rhbg mediate ammonia excretion by ionocytes and keratinocytes in the skin of zebrafish larvae: H+-ATPase-linked active ammonia excretion by ionocytes . Am J Physiol Regul Integr Comp Physiol ; published ahead of print April 17, 2013, doi:10.1152/ajpregu.00550.2012. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords Diet-Induced Obesity NADPH oxidase high-fat high-sucrose endothelial nitric oxide synthase uncoupling high-intensity interval training Article Abstract METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Regulatory, Integrative and Comparative Physiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. 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Wingard American Journal of Physiology - Regulatory, Integrative and Comparative Physiology Aug 2013, 305 (4) R423-R434; DOI: 10.1152/ajpregu.00049.2013 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Functional adaptation of bovine mesenteric lymphatic vessels to mesenteric venous hypertension CNS neuroplasticity and salt-sensitive hypertension induced by prior treatment with subpressor doses of ANG II or aldosterone A model-based approach to investigating the pathophysiological mechanisms of hypertension and response to antihypertensive therapies: extending the Guyton model Show more Fluid and Electrolyte Homeostasis Related Articles No related articles found. 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Exercise prevents Western diet-associated erectile dysfunction and coronary artery endothelial dysfunction: response to acute apocynin and sepiapterin treatment

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Publisher
The American Physiological Society
Copyright
Copyright © 2013 the American Physiological Society
ISSN
0363-6119
eISSN
1522-1490
DOI
10.1152/ajpregu.00049.2013
pmid
23761637
Publisher site
See Article on Publisher Site

Abstract

REFERENCES 1. ↵ Adams V , Linke A , Krankel N , Erbs S , Gielen S , Möbius-Winkler S , Gummert JF , Mohr FW , Schuler G , Hambrecht R . Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease . Circulation 111 : 555 – 562 , 2005 . OpenUrl Abstract / FREE Full Text 2. ↵ Alp NJ , Channon KM . Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease . Arterioscler Thromb Vasc Biol 24 : 413 – 420 , 2004 . OpenUrl Abstract / FREE Full Text 3. ↵ Anderson EJ , Yamazaki H , Neufer PD . Induction of endogenous uncoupling protein 3 suppresses mitochondrial oxidant emission during fatty acid-supported respiration . J Biol Chem 282 : 31257 – 31266 , 2007 . OpenUrl Abstract / FREE Full Text 4. ↵ Angulo J , Peiró C , Cuevas P , Gabancho S , Fernández A , González-Corrochano R , La Fuente JM , Baron AD , Chen KS , Saenz de Tejada I . The novel antioxidant, AC3056 (2,6-di-t-butyl-4-((dimethyl-4-methoxyphenylsilyl) methyloxy) phenol), reverses erectile dysfunction in diabetic rats and improves NO-mediated responses in penile tissue from diabetic men . J Sex Med 6 : 373 – 387 , 2009 . OpenUrl CrossRef Medline 5. ↵ Ayta IA , McKinlay JB , Krane RJ . The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences . BJU Int 84 : 50 – 56 , 1999 . OpenUrl CrossRef Medline Web of Science 6. ↵ Bergholm R , Mäkimattila S , Valkonen M , Liu ML , Lahdenperä S , Taskinen MR , Sovijärvi A , Malmberg P , Yki-Järvinen H . Intense physical training decreases circulating antioxidants and endothelium-dependent vasodilation in vivo . Atherosclerosis 145 : 341 – 349 , 1999 . OpenUrl CrossRef Medline Web of Science 7. ↵ Bivalacqua TJ , Usta MF , Kendirci M , Pradhan L , Alvarez X , Champion HC , Kadowitz PJ , Hellstrom WJG . Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy . J Sex Med 2 : 187 – 198 , 2005 . OpenUrl CrossRef Medline Web of Science 8. ↵ Borgquist R , Gudmundsson P , Winter R , Nilsson P , Willenheimer R . Erectile dysfunction in healthy subjects predicts reduced coronary flow velocity reserve . Int J Cardiol 112 : 166 – 170 , 2006 . OpenUrl CrossRef Medline Web of Science 9. ↵ Cai H , Harrison DG . Endothelial dysfunction in cardiovascular disease: the role of oxidant stress . Circ Res 87 : 840 – 844 , 2000 . OpenUrl Abstract / FREE Full Text 10. ↵ Castor LR , Locatelli KA , Ximenes VF . Pro-oxidant activity of apocynin radical . Free Radic Biol Med 48 : 1636 – 1643 , 2010 . OpenUrl CrossRef Medline 11. ↵ Channon KM . Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease . Trends Cardiovasc Med 14 : 323 – 327 , 2004 . 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J Exp Med 189 : 1699 – 1706 , 1999 . OpenUrl Abstract / FREE Full Text Previous Next Back to top About the Cover About the Cover Cover image Image 1: Scully CG, Mitrou N, Braam B, Cupples WA, Chon KH. Detecting physiological systems with laser speckle perfusion imaging of the renal cortex . Am J Physiol Regul Integr Comp Physiol ; published ahead of print April 3, 2013, doi:10.1152/ajpregu.00002.2013. Image 2: Roy A, Derakhshan F, Wilson RJ. PACAP engages multiple signaling pathways within the carotid body to initiate excitatory responses in respiratory and sympathetic chemosensory afferents . Am J Physiol Regul Integr Comp Physiol ; published ahead of print April 17, 2013, doi:10.1152/ajpregu.00465.2012. Image 3: Shih T, Horng J, Lai Y, Lin L. Rhcg1 and Rhbg mediate ammonia excretion by ionocytes and keratinocytes in the skin of zebrafish larvae: H+-ATPase-linked active ammonia excretion by ionocytes . Am J Physiol Regul Integr Comp Physiol ; published ahead of print April 17, 2013, doi:10.1152/ajpregu.00550.2012. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords Diet-Induced Obesity NADPH oxidase high-fat high-sucrose endothelial nitric oxide synthase uncoupling high-intensity interval training Article Abstract METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Regulatory, Integrative and Comparative Physiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Exercise prevents Western diet-associated erectile dysfunction and coronary artery endothelial dysfunction: response to acute apocynin and sepiapterin treatment Message Subject (Your Name) has sent you a message from Regulatory, Integrative and Comparative Physiology Message Body (Your Name) thought you would like to see the Regulatory, Integrative and Comparative Physiology web site. Your Personal Message Print Citation Tools Exercise prevents Western diet-associated erectile dysfunction and coronary artery endothelial dysfunction: response to acute apocynin and sepiapterin treatment Justin D. La Favor , Ethan J. Anderson , Jillian T. Dawkins , Robert C. Hickner , Christopher J. Wingard American Journal of Physiology - Regulatory, Integrative and Comparative Physiology Aug 2013, 305 (4) R423-R434; DOI: 10.1152/ajpregu.00049.2013 Citation Manager Formats BibTeX EndNote (tagged) EndNote 8 (xml) RefWorks Tagged RIS Medlars Bookends Mendeley Request Permissions Share Exercise prevents Western diet-associated erectile dysfunction and coronary artery endothelial dysfunction: response to acute apocynin and sepiapterin treatment Exercise prevents Western diet-associated erectile dysfunction and coronary artery endothelial dysfunction: response to acute apocynin and sepiapterin treatment Justin D. La Favor , Ethan J. Anderson , Jillian T. Dawkins , Robert C. Hickner , Christopher J. Wingard American Journal of Physiology - Regulatory, Integrative and Comparative Physiology Aug 2013, 305 (4) R423-R434; DOI: 10.1152/ajpregu.00049.2013 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Functional adaptation of bovine mesenteric lymphatic vessels to mesenteric venous hypertension CNS neuroplasticity and salt-sensitive hypertension induced by prior treatment with subpressor doses of ANG II or aldosterone A model-based approach to investigating the pathophysiological mechanisms of hypertension and response to antihypertensive therapies: extending the Guyton model Show more Fluid and Electrolyte Homeostasis Related Articles No related articles found. 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Published: Aug 15, 2013

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