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Exercise and diet reduce muscle insulin resistance in obese Zucker rat

Exercise and diet reduce muscle insulin resistance in obese Zucker rat IVY, J.L.,W.M. SHERMAN,~. L. CUTLER, A.L. KATZ. reduce in obese Zucker rat. Am. J. Physiol. 251 (Endocrinol. Metab. 14): E299E305, 1986.-Two treatments that increase skeletal action are training high-carbohydrate . The purpose of the present study was to determine whether training a high in carbohydrates could function synergistically to reduce the in the obese Zucker rat. Obese rats 4 wk of age were romly assigned to an or sedentary group. Each group was subdivided with one-half of the rats fed a high-carbohydrate one-half fed a high-fat . Lean Zucker rats fed the high-fat were used as controls. was assessed during hindlimb perfusion with a submaximally stimulating concentration of . training the high-carbohydrate increased the rate of glucose uptake in the obese rat 46 53%, respectively. More importantly, the combined effect of training high-carbohydrate was greater than the sum of their individual effects. Glycogen synthesis paralleled glucose uptake was the major pathway for intracellular glucose disposal. glucose uptake for -trained, high-carbohydrate fed obese rats was comparable with that of lean controls. It is concluded that training the high-carbohydrate functioned synergistically to reduce the in the obese rat. ulated glucose uptake than the of rats fed a highfat or mixed http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Exercise and diet reduce muscle insulin resistance in obese Zucker rat

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Publisher
The American Physiological Society
Copyright
Copyright © 1986 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
Publisher site
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Abstract

IVY, J.L.,W.M. SHERMAN,~. L. CUTLER, A.L. KATZ. reduce in obese Zucker rat. Am. J. Physiol. 251 (Endocrinol. Metab. 14): E299E305, 1986.-Two treatments that increase skeletal action are training high-carbohydrate . The purpose of the present study was to determine whether training a high in carbohydrates could function synergistically to reduce the in the obese Zucker rat. Obese rats 4 wk of age were romly assigned to an or sedentary group. Each group was subdivided with one-half of the rats fed a high-carbohydrate one-half fed a high-fat . Lean Zucker rats fed the high-fat were used as controls. was assessed during hindlimb perfusion with a submaximally stimulating concentration of . training the high-carbohydrate increased the rate of glucose uptake in the obese rat 46 53%, respectively. More importantly, the combined effect of training high-carbohydrate was greater than the sum of their individual effects. Glycogen synthesis paralleled glucose uptake was the major pathway for intracellular glucose disposal. glucose uptake for -trained, high-carbohydrate fed obese rats was comparable with that of lean controls. It is concluded that training the high-carbohydrate functioned synergistically to reduce the in the obese rat. ulated glucose uptake than the of rats fed a highfat or mixed

Journal

AJP - Endocrinology and Metabolism – The American Physiological Society

Published: Sep 1, 1986

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