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Journals Physiological Reviews Volume 92 Issue 1

Abstract Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly contribute to vascular and cardiac physiology. The contribution of EETs to vascular and cardiac function is further influenced by soluble epoxide hydrolase (sEH) that degrades EETs to diols. Vascular actions of EETs include dilation and angiogenesis. EETs also decrease inflammation and platelet aggregation and in general act to maintain vascular homeostasis. Myocyte contraction and increased coronary blood flow are the two primary EET actions in the heart. EET cell signaling mechanisms are tissue and organ specific and provide significant evidence for the existence of EET receptors. Additionally, pharmacological and genetic manipulations of EETs and sEH have demonstrated a contribution for this metabolic pathway to cardiovascular diseases. Given the impact of EETs to cardiovascular physiology, there is emerging evidence that development of EET-based therapeutics will be beneficial for cardiovascular diseases. « Previous | Next Article » Table of Contents This Article doi: 10.​1152/​physrev.​00021.​2011 Physiol Rev January 2012 vol. 92 no. 1 101-130 » Abstract Free Full Text Free to you Full Text (PDF) Free to you Classifications Article Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Imig, J. D. PubMed Articles by Imig, J. D. Related Content Load related web page information Current Issue January 2012, 92 (1) Alert me to new issues of Physiol Rev About the Journal Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2012 the American Physiological Society Print ISSN: 0031-9333 Online ISSN: 1522-1210 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview();

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Epoxides and Soluble Epoxide Hydrolase in Cardiovascular Physiology

Imig, John D.
Physiological Reviews , Volume 92 (1): 101
The American Physiological Society – Jan 1, 2012

More Info
  • Publisher American Physiological Society
  • Copyright Copyright © 2012 the American Physiological Society
  • ISSN 0031-9333
  • eISSN 1522-1210
  • D.O.I. 10.1152/physrev.00021.2011
  • Publisher site Get PDF  

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