Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Enzymatic Basis for Active Transport of Na + and K + Across Cell Membrane

Enzymatic Basis for Active Transport of Na + and K + Across Cell Membrane Institut, Aarhus Universitet, Aarhus, Denmark Introduction. Afhnity for Monovalent Cations. ............................................. Relationship of Enzyme System to ATP. ...................................... Isolation of Enzyme System from Other Cells with Active Transport of and K+ ................................................................. Location of Enzyme System in the Cell. ...................................... Effect of Cardiac Glycosides. ................................................ Quantitative Relation between Effect of Na+ + K+ on Enzyme System Active Transport in Intact Cell. .......................................... Nature of Enzyme System. .................................................. Relation of (Na + + K+)-Activated Enzyme System to Active Transport Cations. ................................................................ Conclusion. ............................................. .................. 597 598 Na+ 602 604 605 and 606 607 of 6 10 6’4 INTRODUCTION Experiments on nerve, muscle, frog skin, red blood cells, and cells from a number of other tissueshave shown that Na+ is transported from the cytoplasm to the interstitial fluid against an electrochemical gradient (for ref. see I I 1). By the definition given by Ussing (I I I), this is called active transport. A transport against an electrochemical gradient requires energy, and it has been shown by experiments on nerve (14-18) and on red blood cell membranes (3 I, 54, I 14) that the energy for active transport of Na+ comesfrom adenosinetriphosphate (ATP), and that inosinetriphosphate (ITP), guanosinetriphosphate (GTP), or uridinetriphosphate http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Physiological Reviews The American Physiological Society

Enzymatic Basis for Active Transport of Na + and K + Across Cell Membrane

J. C. Skou
Physiological Reviews , Volume 45: 596 – Jul 1, 1965
Download PDF
23 pages

Loading next page...
 
/lp/the-american-physiological-society/enzymatic-basis-for-active-transport-of-na-and-k-across-cell-membrane-OX7d50MI0h

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
The American Physiological Society
Copyright
Copyright © 1965 the American Physiological Society
ISSN
0031-9333
eISSN
1522-1210
Publisher site
See Article on Publisher Site

Abstract

Institut, Aarhus Universitet, Aarhus, Denmark Introduction. Afhnity for Monovalent Cations. ............................................. Relationship of Enzyme System to ATP. ...................................... Isolation of Enzyme System from Other Cells with Active Transport of and K+ ................................................................. Location of Enzyme System in the Cell. ...................................... Effect of Cardiac Glycosides. ................................................ Quantitative Relation between Effect of Na+ + K+ on Enzyme System Active Transport in Intact Cell. .......................................... Nature of Enzyme System. .................................................. Relation of (Na + + K+)-Activated Enzyme System to Active Transport Cations. ................................................................ Conclusion. ............................................. .................. 597 598 Na+ 602 604 605 and 606 607 of 6 10 6’4 INTRODUCTION Experiments on nerve, muscle, frog skin, red blood cells, and cells from a number of other tissueshave shown that Na+ is transported from the cytoplasm to the interstitial fluid against an electrochemical gradient (for ref. see I I 1). By the definition given by Ussing (I I I), this is called active transport. A transport against an electrochemical gradient requires energy, and it has been shown by experiments on nerve (14-18) and on red blood cell membranes (3 I, 54, I 14) that the energy for active transport of Na+ comesfrom adenosinetriphosphate (ATP), and that inosinetriphosphate (ITP), guanosinetriphosphate (GTP), or uridinetriphosphate

Journal

Physiological Reviews – The American Physiological Society

Published: Jul 1, 1965

There are no references for this article.