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Eicosanoid balance and perfusion redistribution of oleic acid-induced acute lung injury

Eicosanoid balance and perfusion redistribution of oleic acid-induced acute lung injury MATERIALS AND METHODS nism for perfusion FLOW REDISTRIBUTION away from edematous lung regions is common in acute . Although the impact of perfusion redistribution on the accumulation or resolution of pulmonary edema still remains uncertain, the mechanisms responsible for this phenomenon probably include some combination of regional vasoconstriction, vascular obstruction, or mechanical compression. In the canine oleic acid (OA) model of acute , recent studies by our group have cast doubt on the importance of either hypoxic vasoconstriction or vascular compression by edema as the principal mechaBLOOD 2126 0161-7567/92 $2.00 Copyright Animal preparation. Twenty-six healthy adult mongrel dogs weighing between 24 and 30 kg were anesthetized with pentobarbital sodium (25-30 mg/kg), paralyzed with pancuronium bromide (4 mg), intubated with a cuffed endotracheal tube, and ventilated (fractional inspired oxygen content = 1.0) with the use of a Harvard pump ventilator at a tidal volume of 15 ml/kg and a respiratory rate adjusted to achieve a normal Pco,. Additional barbiturate and muscle relaxant were administered as necessary. Through bilateral femoral incisions, a balloon-tipped Physiological Society 0 1992 the American pulmonary artery catheter and a lOO=cm 6.3-Fr pig-tailed catheter were positioned in the pulmonary artery under fluoroscopic visualization. A 7-c& &gauge http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Eicosanoid balance and perfusion redistribution of oleic acid-induced acute lung injury

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Publisher
The American Physiological Society
Copyright
Copyright © 1992 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
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Abstract

MATERIALS AND METHODS nism for perfusion FLOW REDISTRIBUTION away from edematous lung regions is common in acute . Although the impact of perfusion redistribution on the accumulation or resolution of pulmonary edema still remains uncertain, the mechanisms responsible for this phenomenon probably include some combination of regional vasoconstriction, vascular obstruction, or mechanical compression. In the canine oleic acid (OA) model of acute , recent studies by our group have cast doubt on the importance of either hypoxic vasoconstriction or vascular compression by edema as the principal mechaBLOOD 2126 0161-7567/92 $2.00 Copyright Animal preparation. Twenty-six healthy adult mongrel dogs weighing between 24 and 30 kg were anesthetized with pentobarbital sodium (25-30 mg/kg), paralyzed with pancuronium bromide (4 mg), intubated with a cuffed endotracheal tube, and ventilated (fractional inspired oxygen content = 1.0) with the use of a Harvard pump ventilator at a tidal volume of 15 ml/kg and a respiratory rate adjusted to achieve a normal Pco,. Additional barbiturate and muscle relaxant were administered as necessary. Through bilateral femoral incisions, a balloon-tipped Physiological Society 0 1992 the American pulmonary artery catheter and a lOO=cm 6.3-Fr pig-tailed catheter were positioned in the pulmonary artery under fluoroscopic visualization. A 7-c& &gauge

Journal

Journal of Applied Physiology – The American Physiological Society

Published: Nov 1, 1992

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