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Effects of wheat germ agglutinin on insulin binding and insulin sensitivity of fat cells

Effects of wheat germ agglutinin on insulin binding and insulin sensitivity of fat cells of Rochester School E267-E275, 1980.-The plant lectin ( , WGA) produces several alterations in the ability of fat cells to bind respond to . Although WGA markedly stimulated glucose oxidation, it caused only a modest stimulation of glucose transport. WGA (0.25-20 pg/ml) increased the binding of by adipocytes, apparently by increasing the binding affinity of the receptor. With low WGA concentrations (0.25-2.5 pg/ml), the elevation in binding was accompanied by an increase in the sensitivity of the adipocytes to stimulation of glucose transport. However, the sensitivity of these cells to vitamin Kg Hz02 was not altered. With higher WGA concentrations (5-20 pg/ml), stimulation of the glucose transport system by , vitamin &, or Hz02 was markedly inhibited, an effect that is reversed by the addition of ovomucoid. These findings suggest that low WGA. concentrations in&ease the affinity of the receptor the sensitivity of the cells. At higher, concentrations, the lectin appears to act at another site(s) to inhibit the activation of the transport system by or other agents. plant lectins; transport receptors; responsiveness; hexose LIVINGSTON,JAMES N., BARBARA J. PURVIS. Effectsof duced alterations in the ability of’ the cells to bind. on binding Sensi- respond to . Small amounts http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Effects of wheat germ agglutinin on insulin binding and insulin sensitivity of fat cells

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Publisher
The American Physiological Society
Copyright
Copyright © 1980 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
Publisher site
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Abstract

of Rochester School E267-E275, 1980.-The plant lectin ( , WGA) produces several alterations in the ability of fat cells to bind respond to . Although WGA markedly stimulated glucose oxidation, it caused only a modest stimulation of glucose transport. WGA (0.25-20 pg/ml) increased the binding of by adipocytes, apparently by increasing the binding affinity of the receptor. With low WGA concentrations (0.25-2.5 pg/ml), the elevation in binding was accompanied by an increase in the sensitivity of the adipocytes to stimulation of glucose transport. However, the sensitivity of these cells to vitamin Kg Hz02 was not altered. With higher WGA concentrations (5-20 pg/ml), stimulation of the glucose transport system by , vitamin &, or Hz02 was markedly inhibited, an effect that is reversed by the addition of ovomucoid. These findings suggest that low WGA. concentrations in&ease the affinity of the receptor the sensitivity of the cells. At higher, concentrations, the lectin appears to act at another site(s) to inhibit the activation of the transport system by or other agents. plant lectins; transport receptors; responsiveness; hexose LIVINGSTON,JAMES N., BARBARA J. PURVIS. Effectsof duced alterations in the ability of’ the cells to bind. on binding Sensi- respond to . Small amounts

Journal

AJP - Endocrinology and Metabolism – The American Physiological Society

Published: Mar 1, 1980

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