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Effects of microgravity and bone morphogenetic protein II on GFAP in rat brain

Effects of microgravity and bone morphogenetic protein II on GFAP in rat brain Abstract This study evaluated effects of bone morphogenetic protein II (BMP) on glial fibrillary acidic protein (GFAP) in the brain of female Fischer 344 rats during 14 days of spaceflight. GFAP mRNA decreased in vehicle-implanted rats flown on the space shuttle by 53 and 48% in the stratum moleculare and stratum lacunosum moleculare hippocampal subregions, respectively. GFAP mRNA was not significantly affected by BMP implantation during spaceflight. Rats returning from space exhibited a 56% increase in serum corticosterone. BMP treatment did not additively increase corticosterone elevations in microgravity but appeared to increase serum corticosterone and reduce GFAP mRNA in the stratum moleculare in control rats. These data suggest that exposure to microgravity reduces GFAP expression in hippocampal astrocytes. hippocampus spaceflight stress glucocorticoids astrocytes glial fibrillary acidic protein Footnotes Address for reprint requests: J. R. Day, Dept. of Biology and Gerontology Center, 208 Erwin Mueller Laboratory, The Pennsylvania State Univ., University Park, PA 16802 (E-mail jrd6@psu.edu ). We thank the National Aeronautics and Space Administration and Dr. William W. Willfinger from the Center for Cell Research at The Pennsylvania State University for providing us with the tissues. We also thank Elizabeth H. Boykin for technical assistance, Dr. William Kramer from the Center for Sports Medicine at The Pennsylvania State University for providing us with the serum corticosterone data, and Asha Patel for original artwork. The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “ advertisement ” in accordance with 18 U.S.C. §1734 solely to indicate this fact. Copyright © 1998 the American Physiological Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Effects of microgravity and bone morphogenetic protein II on GFAP in rat brain

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Publisher
The American Physiological Society
Copyright
Copyright © 2011 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
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Abstract

Abstract This study evaluated effects of bone morphogenetic protein II (BMP) on glial fibrillary acidic protein (GFAP) in the brain of female Fischer 344 rats during 14 days of spaceflight. GFAP mRNA decreased in vehicle-implanted rats flown on the space shuttle by 53 and 48% in the stratum moleculare and stratum lacunosum moleculare hippocampal subregions, respectively. GFAP mRNA was not significantly affected by BMP implantation during spaceflight. Rats returning from space exhibited a 56% increase in serum corticosterone. BMP treatment did not additively increase corticosterone elevations in microgravity but appeared to increase serum corticosterone and reduce GFAP mRNA in the stratum moleculare in control rats. These data suggest that exposure to microgravity reduces GFAP expression in hippocampal astrocytes. hippocampus spaceflight stress glucocorticoids astrocytes glial fibrillary acidic protein Footnotes Address for reprint requests: J. R. Day, Dept. of Biology and Gerontology Center, 208 Erwin Mueller Laboratory, The Pennsylvania State Univ., University Park, PA 16802 (E-mail jrd6@psu.edu ). We thank the National Aeronautics and Space Administration and Dr. William W. Willfinger from the Center for Cell Research at The Pennsylvania State University for providing us with the tissues. We also thank Elizabeth H. Boykin for technical assistance, Dr. William Kramer from the Center for Sports Medicine at The Pennsylvania State University for providing us with the serum corticosterone data, and Asha Patel for original artwork. The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “ advertisement ” in accordance with 18 U.S.C. §1734 solely to indicate this fact. Copyright © 1998 the American Physiological Society

Journal

Journal of Applied Physiology – The American Physiological Society

Published: Aug 1, 1998

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