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DANIEL R. RICHARDSON Kentucky 40536 of Biology, Kentucky State Uniuersity, Frankfort 40601; of Physiology Biophysics, University of Kentucky, Lexington, BENNETT,~HARLES H., DANIEL R. RICHARDSON. Effects of chronic tobacco smoke exposure on arterial pressure . Am. J. Physiol. 247 (Heart Circ. Physiol. 16): H556H562, 19&L-The purpose of this study was to determine the effects of long-term consumption of tobacco smoke on arterial pressure . Male Sprague-Dawley rats were administered tobacco smoke for 6-8 mo. Two groups of animals (A B) received tobacco smoke containing different levels of nicotine (group A: high nicotine, 4 mg/cigarette; group B: low nicotine, 1 mg/cigarette), while a third group (C) served as a sham control by receiving only puffs of room air. Reflex adjustments in mean arterial pressure (MAP), heart rate (HR), lower body flow, lower body vascular resistance were compared between the three groups. In the anesthetized control state, no significant difference existed for the cardiovascular parameters measured in the three groups. However, perturbating the cardiovascular system by reducing central volume via a 60â head-up tilt elicited less of a fall in MAP in the two smoke groups compared with the sham group. Percent decreases in MAP follow: group A, 23%; group B,
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Oct 1, 1984
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