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Effects of autonomic activity and changes in heart rate on atrioventricular conduction

Effects of autonomic activity and changes in heart rate on atrioventricular conduction diminishes the responsiveness of the heart to a given level of sympathetic activity (31). Vagal ulation results in a diminished chronotropic response of the sinoatrial (SA) nodal and AV junctional pacemakers and in a decreased inotropic response of the atria1 and ventricular myocardium to sympathetic ulation (15, 30, 35). There does not appear to be a significant interaction involved in the autonomic control of AV conduction, however (17). Levy and Zieske (17) found that the response of the AV conduction system to combined sympathetic and vagal ulation was virtually equal to the algebraic sum of the individual responses to ulation of each autonomic division separately. In their study, however, heart rate was not controlled during the measurements of AV conduction time. Therefore, a possible sympathetic-vagal interaction may have been masked by the indirect effects of the concomitant changes in heart rate. In the present study, a factorial experimental design was used in order to quantify the direct effects of vagal activity, sympathetic activity, and heart rate on AV conduction and to assessthe magnitudes of the interaction among these important determinants of AV conduction. METHODS ACTIVITY directly facilitates and parasympathetic activity directly retards atrioventricular (AV) conduction (7, 10, 17, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Effects of autonomic activity and changes in heart rate on atrioventricular conduction

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Publisher
The American Physiological Society
Copyright
Copyright © 1982 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
See Article on Publisher Site

Abstract

diminishes the responsiveness of the heart to a given level of sympathetic activity (31). Vagal ulation results in a diminished chronotropic response of the sinoatrial (SA) nodal and AV junctional pacemakers and in a decreased inotropic response of the atria1 and ventricular myocardium to sympathetic ulation (15, 30, 35). There does not appear to be a significant interaction involved in the autonomic control of AV conduction, however (17). Levy and Zieske (17) found that the response of the AV conduction system to combined sympathetic and vagal ulation was virtually equal to the algebraic sum of the individual responses to ulation of each autonomic division separately. In their study, however, heart rate was not controlled during the measurements of AV conduction time. Therefore, a possible sympathetic-vagal interaction may have been masked by the indirect effects of the concomitant changes in heart rate. In the present study, a factorial experimental design was used in order to quantify the direct effects of vagal activity, sympathetic activity, and heart rate on AV conduction and to assessthe magnitudes of the interaction among these important determinants of AV conduction. METHODS ACTIVITY directly facilitates and parasympathetic activity directly retards atrioventricular (AV) conduction (7, 10, 17,

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: Oct 1, 1982

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