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stitut P. K~0~~~.ElffectsofANP-(95126) dogs before after duction of . Am. J. Physiol. 259 ( Circ. Physiol. 28): H1643-H1648, 1990. conscious dogs out congestive , we vestigated hemodynamic, hormonal, renal effects of a new natriuretic peptide [ANP-(95~126)]. Unlike ANP-(99126), which is secreted the rapidly activated the kidney, most likely origates from the kidney is not destroyed by proteolysis membrane preparations of kidney cortex. animals travenous ANP(95-126) significantly decreased mean arterial pressure, cardiac output, stroke volume, right atria1 pressure creased rate out changg mean pulmonary arterial pressure total peripheral vascular resistance. dogs congestive , showed no effects on mean arterial pressure, cardiac output, stroke volume, peripheral vascular resistance but reduced right atria1 pressure pulmonary arterial pressure. Both, dogs before after the duction of , the new peptide led to a significant crease of ure flow sodium chloride excretion. dogs there were direct dications for a small hibitory effect on ren aldosterone secretion. Thus, contrast to the considerable attenuation of renal effects of ANP-(99-126) , the efficacy of on renal excretory function is well preserved, which may be because of the lack of proteolytic degradation the kidney. These results suggest that may have clical implications for the treatment of patients congestive
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Dec 1, 1990
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