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Effects of 15-hydroperoxy-eicosatetraenoic acid (15-HPETE) on cerebral arterioles of cats

Effects of 15-hydroperoxy-eicosatetraenoic acid (15-HPETE) on cerebral arterioles of cats Prostaglandin hydroperoxidase is relatively nonspecific; in addition to its natural substrate, PGGz, it also acts on other hydroperoxy acids (5, 15). It is known that &hydroperoxy-eicosatetraenoic acid (15-HPETE) is as good or a better substrate for the prostaglandin hydroperoxidase than PGGz (5, 15). If the oxygen radicals responsible for the vascular injury from arachidonate or PGGB are indeed the result of the hydroperoxidase reaction, 15-HPETE should also be capable of inducing the same type of injury, and this injury should be inhibited by pretreatment with oxygen radical scavengers. We therefore tested the effect of topical application of l5HPETE on cerebral vessels with and without superoxide dismutase (SOD) and catalase or a combination of the two. METHODS Experiments were carried out in cats anesthetized with pentobarbital sodium (30 mg/kg iv). After completion of tracheostomy, each animal was ventilated with a positive pressure respirator and received 0.5 mg/kg decamethonium bromide for skeletal muscle paralysis. The endexpiratory CO2 of the animal was monitored continuously with a Beckman infrared CO, analyzer and was maintained at a constant level of about 30 mmHg by adjustment of the respirator rate and volume. Arterial blood pressure was measured with a Statham pressure transducer connected to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Effects of 15-hydroperoxy-eicosatetraenoic acid (15-HPETE) on cerebral arterioles of cats

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Publisher
The American Physiological Society
Copyright
Copyright © 1984 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
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Abstract

Prostaglandin hydroperoxidase is relatively nonspecific; in addition to its natural substrate, PGGz, it also acts on other hydroperoxy acids (5, 15). It is known that &hydroperoxy-eicosatetraenoic acid (15-HPETE) is as good or a better substrate for the prostaglandin hydroperoxidase than PGGz (5, 15). If the oxygen radicals responsible for the vascular injury from arachidonate or PGGB are indeed the result of the hydroperoxidase reaction, 15-HPETE should also be capable of inducing the same type of injury, and this injury should be inhibited by pretreatment with oxygen radical scavengers. We therefore tested the effect of topical application of l5HPETE on cerebral vessels with and without superoxide dismutase (SOD) and catalase or a combination of the two. METHODS Experiments were carried out in cats anesthetized with pentobarbital sodium (30 mg/kg iv). After completion of tracheostomy, each animal was ventilated with a positive pressure respirator and received 0.5 mg/kg decamethonium bromide for skeletal muscle paralysis. The endexpiratory CO2 of the animal was monitored continuously with a Beckman infrared CO, analyzer and was maintained at a constant level of about 30 mmHg by adjustment of the respirator rate and volume. Arterial blood pressure was measured with a Statham pressure transducer connected to

Journal

AJP - Heart and Circulatory Physiology – The American Physiological Society

Published: Oct 1, 1984

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