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Effect of iodine deficiency and cold exposure on thyroxine 5'-deiodinase activity in various rat tissues

Effect of iodine deficiency and cold exposure on thyroxine 5'-deiodinase activity in various rat... CARMEN C. PAZOS-MOURA, EGBERTO G. MOURA, MARTHA L. DORRIS, STEFAN REHNMARK, LUIS MELENDEZ, J. ENRIQUE SILVA, ALVIN TAUROG Department Pharmacology, University Texas Southwestern Medical Center, Dallas, Texas 75235; Thyroid Unit, Beth Israel Hospital, Harvard Medical School, Bost, Massachusetts 02215 L. DORRIS, PAZOS-MOUBA, CARMEN C., EGBERTO G. MOURA, MARTHA STEFAN REHNMARK, LUIS MELENDEZ, J. ENRIQUE SILVA, ALVIN TAUROG. exposure thyroxine 5’-deiodinase activity in various rat tissues. Am. J. Physiol. 260 (Endocril. Metab. 23): E175-El82, 1991.-We measured thyroxine 5’-deiodinase I (T,YD-I) activity in thyroid, liver, kidney thyroxine 5’-deiodinase II (T45’D-II) activity in brown adipose tissue (BAT) in rats a low- diet (LID) to test the possibility that increased deiodinase activity in these tissues might ctribute to the maintenance the serum 3,5,3’-triiodothyrine (T3) level. Ctrol rats received LID plus KI. Experiments were also performed with LID LID plus KI rats exposed to . T,5’D-I activity was greatly increased in the thyroids LID rats but t in liver or kidney. We csider it likely that increased thyroxine (T,)-to-T, cversi in the greatly enlarged thyroids LID rats ctributed to the maintenance serum TX. T45’D-II activity in BAT was markedly increased in LID rats was further greatly increased exposure. However, we were unable to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Effect of iodine deficiency and cold exposure on thyroxine 5'-deiodinase activity in various rat tissues

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Publisher
The American Physiological Society
Copyright
Copyright © 1991 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
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Abstract

CARMEN C. PAZOS-MOURA, EGBERTO G. MOURA, MARTHA L. DORRIS, STEFAN REHNMARK, LUIS MELENDEZ, J. ENRIQUE SILVA, ALVIN TAUROG Department Pharmacology, University Texas Southwestern Medical Center, Dallas, Texas 75235; Thyroid Unit, Beth Israel Hospital, Harvard Medical School, Bost, Massachusetts 02215 L. DORRIS, PAZOS-MOUBA, CARMEN C., EGBERTO G. MOURA, MARTHA STEFAN REHNMARK, LUIS MELENDEZ, J. ENRIQUE SILVA, ALVIN TAUROG. exposure thyroxine 5’-deiodinase activity in various rat tissues. Am. J. Physiol. 260 (Endocril. Metab. 23): E175-El82, 1991.-We measured thyroxine 5’-deiodinase I (T,YD-I) activity in thyroid, liver, kidney thyroxine 5’-deiodinase II (T45’D-II) activity in brown adipose tissue (BAT) in rats a low- diet (LID) to test the possibility that increased deiodinase activity in these tissues might ctribute to the maintenance the serum 3,5,3’-triiodothyrine (T3) level. Ctrol rats received LID plus KI. Experiments were also performed with LID LID plus KI rats exposed to . T,5’D-I activity was greatly increased in the thyroids LID rats but t in liver or kidney. We csider it likely that increased thyroxine (T,)-to-T, cversi in the greatly enlarged thyroids LID rats ctributed to the maintenance serum TX. T45’D-II activity in BAT was markedly increased in LID rats was further greatly increased exposure. However, we were unable to

Journal

AJP - Endocrinology and Metabolism – The American Physiological Society

Published: Feb 1, 1991

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