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Effect of inhibitors and weak bases on electrophysiology and secretion in frog stomach

Effect of inhibitors and weak bases on electrophysiology and secretion in frog stomach of Alabama, W. S. Birgham, Alabama 35294 SERS, S. S., J, A. R. L. W. S. . Effect of inhibitors OIZ electrophyshgy secreti in frog sto172ach. Am. J. Physl. 234(Z): E120-E128, 1978 or Am. J. Physl.; Endocrinol. Metab. Gastrointest. Physl. 3(2): E120-E128, 1978. -We find in studies the in vitro frog gastric mucosa that ctrary to prevus reports by others imidazole does not inhibit H+ secreti. With a Rana pipiens in vitro preparati, we found the following. Under appropriate cditis imidazole added to the nutrient side markedly decreases the measured H+ rate, but this decrease results from neutralizati of secreted H+ by the imidazole diffusing from the nutrient to the secretory side. Inhibiti of H+ secreti by thcyanate is substantially reversed by imidazole. Another base, aopyrine, acts similarly to imidazole. Although thcyanate inhibiti of H+ secreti is reversed by these , they ly partially reverse the thcyanate effects the electrophyslogical characteristics of the mucosa. Nitrite inhibiti of H+ secreti is not reversed by aopyrine, but is slightly reversed by imidazole, With Cl --free bathing media, the PD is inverted (the nutrient side becomes negative), the H+ rate is reduced but still finite measurable. Under these cditis, thcyanate abolishes http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Gastrointestinal and Liver Physiology The American Physiological Society

Effect of inhibitors and weak bases on electrophysiology and secretion in frog stomach

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Publisher
The American Physiological Society
Copyright
Copyright © 1978 the American Physiological Society
ISSN
0193-1857
eISSN
1522-1547
Publisher site
See Article on Publisher Site

Abstract

of Alabama, W. S. Birgham, Alabama 35294 SERS, S. S., J, A. R. L. W. S. . Effect of inhibitors OIZ electrophyshgy secreti in frog sto172ach. Am. J. Physl. 234(Z): E120-E128, 1978 or Am. J. Physl.; Endocrinol. Metab. Gastrointest. Physl. 3(2): E120-E128, 1978. -We find in studies the in vitro frog gastric mucosa that ctrary to prevus reports by others imidazole does not inhibit H+ secreti. With a Rana pipiens in vitro preparati, we found the following. Under appropriate cditis imidazole added to the nutrient side markedly decreases the measured H+ rate, but this decrease results from neutralizati of secreted H+ by the imidazole diffusing from the nutrient to the secretory side. Inhibiti of H+ secreti by thcyanate is substantially reversed by imidazole. Another base, aopyrine, acts similarly to imidazole. Although thcyanate inhibiti of H+ secreti is reversed by these , they ly partially reverse the thcyanate effects the electrophyslogical characteristics of the mucosa. Nitrite inhibiti of H+ secreti is not reversed by aopyrine, but is slightly reversed by imidazole, With Cl --free bathing media, the PD is inverted (the nutrient side becomes negative), the H+ rate is reduced but still finite measurable. Under these cditis, thcyanate abolishes

Journal

AJP - Gastrointestinal and Liver PhysiologyThe American Physiological Society

Published: Feb 1, 1978

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