Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
Abstract The present study examined the effect of high-intensity exercise training on muscle sarcolemmal lactate/H + transport and the monocarboxylate transporters (MCT1 and MCT4) as well as lactate and H + release during intense exercise in humans. One-legged knee-extensor exercise training was performed for 8 wk, and biopsies were obtained from untrained and trained vastus lateralis muscle. The rate of lactate/H + transport determined in sarcolemmal giant vesicles was 12% higher ( P < 0.05) in the trained than in untrained muscle ( n = 7). The content of MCT1 and MCT4 protein was also higher (76 and 32%, respectively; n = 4) in trained muscle. Release of lactate and H + from the quadriceps muscle at the end of intense exhaustive knee-extensor exercise was similar in the trained and untrained leg, although the estimated muscle intracellular-to-interstitial gradients of lactate and H + were lower ( P < 0.05) in the trained than in the untrained muscle. The present data show that intense exercise training can increase lactate/H + transport capacity in human skeletal muscle as well as improve the ability of the muscle to release lactate and H + during contractions. monocarboxylate transporters blood flow pH Footnotes Address for reprint requests: H. Pilegaard, August Krogh Institute, Univ. of Copenhagen, Universitetsparken 13, 2100 Copenhagen, Denmark. This research was supported by the Danish National Research Foundation (J.nr. 504–14). In addition, support was obtained from Team Danmark and Idrættens Forskningsråd. The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “ advertisement ” in accordance with 18 U.S.C. §1734 solely to indicate this fact. Copyright © 1999 the American Physiological Society
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Feb 1, 1999
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.