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Effect of forebrain lesions on response to chronic intraventricular angiotensin II

Effect of forebrain lesions on response to chronic intraventricular angiotensin II GREGORY D., WILLIAM J. MARK E. . Effect of forebrain lesions on response to chronic intraventricular angiotensin II. Am. J. Physiol. 244 (Regulatory Integrative Comp. Physiol. 13): R45-R50, 1983.-We previously reported that chronic (10 days) intracerebroventricular (ivt) infusion of angiotensin II (ANG II) into conscious rabbits produced a significant rise in mean arterial pressure (MAP), water intake (WI), urinary sodium excretion (U,,V), a significant fall in plasma sodium (PN~) potassium (Pk) concentrations. Urinary potassium excretion (UkV) body fluid volume were not changed significantly. In the present experiments, &n&r chronic infusions were carried out in intact rabbits in rabbits with an electrolytic lesion placed in the anteroventral third cerebral ventricle (AV3V) region. Integrity of the AV3V area is essential for normal expression of a variety of acute physiological responses to ANG II injected into the brain. In rabbits with AV3V lesions, chronic ivt infusion of ANG II did not significantly alter MAP, but WI fractional UNaV increased, PNa decreased in a er identical to that of sham-lesioned control rabbits. Plasma extracellular fluid volumes increased, body weight food intake decreased in all rabbits during ANG II infusion, but to a slightly greater extent in the AV3Vlesioned rabbits. We conclude that http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

Effect of forebrain lesions on response to chronic intraventricular angiotensin II

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Publisher
The American Physiological Society
Copyright
Copyright © 1983 the American Physiological Society
ISSN
0363-6119
eISSN
1522-1490
Publisher site
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Abstract

GREGORY D., WILLIAM J. MARK E. . Effect of forebrain lesions on response to chronic intraventricular angiotensin II. Am. J. Physiol. 244 (Regulatory Integrative Comp. Physiol. 13): R45-R50, 1983.-We previously reported that chronic (10 days) intracerebroventricular (ivt) infusion of angiotensin II (ANG II) into conscious rabbits produced a significant rise in mean arterial pressure (MAP), water intake (WI), urinary sodium excretion (U,,V), a significant fall in plasma sodium (PN~) potassium (Pk) concentrations. Urinary potassium excretion (UkV) body fluid volume were not changed significantly. In the present experiments, &n&r chronic infusions were carried out in intact rabbits in rabbits with an electrolytic lesion placed in the anteroventral third cerebral ventricle (AV3V) region. Integrity of the AV3V area is essential for normal expression of a variety of acute physiological responses to ANG II injected into the brain. In rabbits with AV3V lesions, chronic ivt infusion of ANG II did not significantly alter MAP, but WI fractional UNaV increased, PNa decreased in a er identical to that of sham-lesioned control rabbits. Plasma extracellular fluid volumes increased, body weight food intake decreased in all rabbits during ANG II infusion, but to a slightly greater extent in the AV3Vlesioned rabbits. We conclude that

Journal

AJP - Regulatory, Integrative and Comparative PhysiologyThe American Physiological Society

Published: Jan 1, 1983

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