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Effect of extracellular ATP on cytosolic Ca2+ concentration in rat pulmonary artery myocytes

Effect of extracellular ATP on cytosolic Ca2+ concentration in rat pulmonary artery myocytes than, Savineau, unpublished results). is released by stimulation of nonadrenergic, noncholinergic nerves in the rat pulmonary artery (13). More recently, it has been observed in the rabbit pulmonary artery that the release of , ADP, AMP, adenosine in response to electrical field stimulation exceeds that of norepinephrine (25). However, can activate various P2 purinoceptors, i.e., P2X, P2Y, P2u purinoceptors that have been identified cloned (6). P2, PBupurinoceptors belong to the G protein-coupled receptor superfamily (18, 32), whereas PzX purinoceptors belong to the family of transmitter-gated ion channels (5, 31). Both P2X P2Y purinoceptors seem to be present in the smooth muscle of human pulmonary artery (17). Moreover, the pulmonary vasoconstrictor response to in vivo depends, at least in part, on the activation of a PzX purinoceptor (16). produces effects via different excitation-coupling mechanisms may play a modulatory role in a variety of pathophysiological processes such as hypoxic pulmonary vasoconstriction (2 1,22), pulmonary hypertension (22>, the cell cycle progression of vascular (20). We thus designed the present experiments to characterize its action on the [Ca2+]i in the rat pulmonary artery. For this purpose, we investigated the effect of other P2 purinoceptor agonists, 2-methylthio- (2-MeS-), cx$-methylene- (a$-Me), UTP, using indo http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Lung Cellular and Molecular Physiology The American Physiological Society

Effect of extracellular ATP on cytosolic Ca2+ concentration in rat pulmonary artery myocytes

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Publisher
The American Physiological Society
Copyright
Copyright © 1996 the American Physiological Society
ISSN
1040-0605
eISSN
1522-1504
Publisher site
See Article on Publisher Site

Abstract

than, Savineau, unpublished results). is released by stimulation of nonadrenergic, noncholinergic nerves in the rat pulmonary artery (13). More recently, it has been observed in the rabbit pulmonary artery that the release of , ADP, AMP, adenosine in response to electrical field stimulation exceeds that of norepinephrine (25). However, can activate various P2 purinoceptors, i.e., P2X, P2Y, P2u purinoceptors that have been identified cloned (6). P2, PBupurinoceptors belong to the G protein-coupled receptor superfamily (18, 32), whereas PzX purinoceptors belong to the family of transmitter-gated ion channels (5, 31). Both P2X P2Y purinoceptors seem to be present in the smooth muscle of human pulmonary artery (17). Moreover, the pulmonary vasoconstrictor response to in vivo depends, at least in part, on the activation of a PzX purinoceptor (16). produces effects via different excitation-coupling mechanisms may play a modulatory role in a variety of pathophysiological processes such as hypoxic pulmonary vasoconstriction (2 1,22), pulmonary hypertension (22>, the cell cycle progression of vascular (20). We thus designed the present experiments to characterize its action on the [Ca2+]i in the rat pulmonary artery. For this purpose, we investigated the effect of other P2 purinoceptor agonists, 2-methylthio- (2-MeS-), cx$-methylene- (a$-Me), UTP, using indo

Journal

AJP - Lung Cellular and Molecular PhysiologyThe American Physiological Society

Published: Sep 1, 1996

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