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Abstract Studies of renal function in four hypertensive patients under various conditions of diet, therapy, and position were undertaken in an effort to clarify their relationship to TH H2 O c and to further illucidate the mechanism by which TH H2 O c is altered. The results indicate that the decrease of TH H2 o c induced by a low-salt diet is not due to the concomitant decrease of glomerular filtration rate, clearance of sodium, or sodium load to the loop of Henle. Acute decrease of GFR by standing position is accompanied by a significant increase of TH H2 o c . It was also shown that the modification of ! occurred apparently independently of the variations in renal plasma flow. Finally it was not possible, in our patients, to detect the actual mechanism by which a low-salt diet decreased TH H2 o c . recumbent and standing position; normal diet; Na-deficient diet Submitted on August 8, 1963 Copyright © 1964 the American Physiological Society
Journal of Applied Physiology – The American Physiological Society
Published: Nov 1, 1964
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