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1, January PHYSIOLOGY Printed in U.S.A. Effect of carbon monoxide in man on reflex vasoconstriction DONALD D. HEISTAD ROBERT C. WHEELER Physiology Laboratory, US Armv Research Institute of Environmental Medicine, Nat&k, Massachusetts HEISTAD, DONALD D., ROBERT C. WHEELER. Effect of carbon monoxide on reflex vasoconstriction in man. J. Appl. Physiol. METHODS 32(l): 7-11. 1972.-The effects of inhalation of carbon monoxide on blood flow to the forearm h on reflex vascular responsiveness were observed in healthy men. Carbon monoxide inhalation causes tissue hypoxia by reducing oxygen saturation by shifting the oxyhemoglobin dissociation curve to the left, but it does not cause a change in arterial oxygen tension. This study was done to determine whether the hypoxia induced by carbon monoxide causes an inhibition of reflex vasoconstrictor responses or whether the presence of a normal arterial oxygen tension allows preservation of vascular responses. Blood flow to the forearm h were measured with plethysmographs arterial pressure was obtained by auscultation. Resting values responses to lower body negative pressure to application of ice to the forehead were compared at three levels of carboxyhemoglobin : 4% (), 19y 0, 2570. There was no evidence of stimulation of the sympathoadrenal system by carbon monoxide:
Journal of Applied Physiology – The American Physiological Society
Published: Jan 1, 1972
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