Early postnatal overnutrition increases adipose tissue accrual in response to a sucrose-enriched diet

Esther Fuente-Martín , Cristina García-Cáceres , Miriam Granado , Miguel A. Sánchez-Garrido , Manuel Tena-Sempere , Laura M. Frago , Jesús Argente , and Julie A. Chowen

doi:10.1152/ajpendo.00618.2011

$Both overnutrition and an incorrect nutrient balance have contributed to the rise in obesity. Moreover, it is now clear that poor nutrition during early life augments the possibility of excess weight gain in later years. Our aim was to determine how neonatal overnutrition affects later responses to a sucrose-enriched diet and whether this varies depending upon when the diet is introduced in postnatal life. Male Wistar rats raised in litters of four or 12 pups were given a 33% sucrose solution instead of water from weaning (day 21) or postnatal day (PND) 65. All rats received normal chow ad libitum until they were euthanized on PND 80. Body weight (BW) and food and liquid intake were monitored throughout the study. Fat mass, adipocyte morphology, serum biochemical and hormonal parameters, and hypothalamic neuropeptide mRNA levels were measured at study termination. Neonatal overnutrition increased food intake, BW, and leptin levels, induced adipocyte hypertrophy, and decreased total ghrelin levels. The sucrose-enriched diet increased total energy intake, adipose accrual, and leptin, adiponectin, and acylated ghrelin levels but decreased BW. Most of these responses were accentuated in neonatally overnourished rats, which also had increased insulin and triglyceride levels. However, long-term sucrose intake induced adipocyte hypertrophy in rats from normal-sized litters but not in neonatally overfed rats. The results reported here indicate that neonatal overnutrition increases the detrimental response to a diet rich in sucrose later in life. Moreover, the timing and duration of the exposure to a sucrose-enriched diet alter the adverse metabolic outcomes. obesity litter size leptin fat mass Copyright © 2012 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print April 17, 2012 , doi: 10.1152/ajpendo.00618.2011 AJP - Endo June 15, 2012 vol. 302 no. 12 E1586-E1598 » Abstract Free Full Text Free to you Full Text (PDF) Free to you All Versions of this Article: ajpendo.00618.2011v1 302/12/E1586 most recent Classifications Article Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Fuente-Martín, E. Articles by Chowen, J. A. PubMed PubMed citation Articles by Fuente-Martín, E. Articles by Chowen, J. A. Related Content Load related web page information Current Content June 15, 2012 Alert me to new issues of AJP - Endo About the Journal Calls for Papers Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2012 the American Physiological Society Print ISSN: 0193-1849 Online ISSN: 1522-1555 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview(); } catch(err) {} var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-189672-30"); pageTracker._setDomainName(".physiology.org"); pageTracker._trackPageview(); } catch(err) {}$

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Early postnatal overnutrition increases adipose tissue accrual in response to a sucrose-enriched diet

Esther Fuente-Martín , Cristina García-Cáceres , Miriam Granado , Miguel A. Sánchez-Garrido , Manuel Tena-Sempere , Laura M. Frago , Jesús Argente , and Julie A. Chowen

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Early postnatal overnutrition increases adipose tissue accrual in response to a sucrose-enriched diet

Esther Fuente-Martín , Cristina García-Cáceres , Miriam Granado , Miguel A. Sánchez-Garrido , Manuel Tena-Sempere , Laura M. Frago , Jesús Argente , and Julie A. Chowen

Follow AJP - Endocrinology and Metabolism , Volume 302 (12): E1586 The American Physiological Society – Jun 15, 2012

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