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Dimethylthiourea does not ameliorate reperfusion lung injury in dogs or rabbits

Dimethylthiourea does not ameliorate reperfusion lung injury in dogs or rabbits MICHAEL J., EMIL Y. CHI, W. CHENEY. Dimethylthiourea fusion edema, because in rabbits induced by phorbol myristate acetate-activated neutrophils can be prevented with the 02 radical scavenger, dimethyl thiourea () (9), we hypothesized that would prevent in dogs. When this hypothesis proved incorrect, a model was established in rabbits to ensure that the observations in the dogs were not species specific. Observations in the rabbit confirmed that also occurred in rabbits could not be ameliorated by . MATERIALS METHODS pulmonary syndrome; edema; pulmonary adult circulation; respiratory distress of a dog after 48 h of ipsilateral pulmonary arterial occlusion results in edema, an inflammatory infiltrate, alveolar capillaries that contain many neutrophil plugs (2,4). The authors previously demonstrated that this could not be prevented by pretreatment with allopurinol (4), suggesting that the mechanism differed from the xanthine oxidase-induced occurring during of ischemic bowel, heart, kidneys, liver, myocardium (1, 14, 18, 21). Because of the inflammatory infiltrate seen in reper Dog studies. We studied 18 mongrel dogs weighing 24 t 1 kg; 9 dogs received , 9 dogs served as untreated controls. Forty-eight hours before study, animals were anesthetized with halothane in a vivarium operating room, a thoracotomy was performed by http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Dimethylthiourea does not ameliorate reperfusion lung injury in dogs or rabbits

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Publisher
The American Physiological Society
Copyright
Copyright © 1988 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
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Abstract

MICHAEL J., EMIL Y. CHI, W. CHENEY. Dimethylthiourea fusion edema, because in rabbits induced by phorbol myristate acetate-activated neutrophils can be prevented with the 02 radical scavenger, dimethyl thiourea () (9), we hypothesized that would prevent in dogs. When this hypothesis proved incorrect, a model was established in rabbits to ensure that the observations in the dogs were not species specific. Observations in the rabbit confirmed that also occurred in rabbits could not be ameliorated by . MATERIALS METHODS pulmonary syndrome; edema; pulmonary adult circulation; respiratory distress of a dog after 48 h of ipsilateral pulmonary arterial occlusion results in edema, an inflammatory infiltrate, alveolar capillaries that contain many neutrophil plugs (2,4). The authors previously demonstrated that this could not be prevented by pretreatment with allopurinol (4), suggesting that the mechanism differed from the xanthine oxidase-induced occurring during of ischemic bowel, heart, kidneys, liver, myocardium (1, 14, 18, 21). Because of the inflammatory infiltrate seen in reper Dog studies. We studied 18 mongrel dogs weighing 24 t 1 kg; 9 dogs received , 9 dogs served as untreated controls. Forty-eight hours before study, animals were anesthetized with halothane in a vivarium operating room, a thoracotomy was performed by

Journal

Journal of Applied Physiology – The American Physiological Society

Published: Nov 1, 1988

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