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KENNEDY, University School of Medicine, Louisiana 70146; Department Corporation, Seattle, Washington of 98101 -a has a beneficial effect in mammalian optic nerve regeneration (2 1), glial cell proliferation, neural differentiation (18). The source of the -a that mediates EAE could be either inside the brain or from peripheral tissues. If originating in the periphery, -a would have to cross the altered BBB. Our previous work (8) has demonstrated that murine -(x crosses the BBB by a saturable transport system different from the systems identified for interleukins (2, 3). - a crosses as an intact molecule to appear in both the parenchyma of the brain the cerebrospinal fluid (8). This raises the question of the role the transport system for -(x plays in EAE. In the following experiments, EAE was induced by immunization of SJL/JCR female mice with a peptide [PLP-( 139-X51)] (25) of myelin proteolipid protein (16). The in cll d ence exceeded 97% in each experiment. In these mice, we studied the temporal spatial changes in the permeability of the BBB to -(x to two traditional markers of BBB integrity, sucrose albumin; the effect of EAE on the saturable component of the -(x transport system; the effects
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Oct 1, 1996
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