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Na+ is subsequently extruded from the cell into the tubule lumen by an electrogenic cation pump that we and others hypothesize to be present in the apical membrane (16,17,25,26). plays the well-known second messenger role, in this case for the mosquito natriuretic peptide (MNP), which we have purified from mosquito heads (4,22-24). MNP, like , is a potent stimulator of traepithelial NaCl and fluid secretion but not of K+ secretion (4, 22, 31). The mechanisms of traepithelial K+ secretion are unknown. Furthermore, it is unknown which tracellular pathways Cl- takes when accompanying traepithelial Naâ and K+ secretion. Failing to observe Clconductances in the basolateral membrane as large as those of K+ and Naâ conductances (27), we have examined this epithelium for evidence of electroneutral Cltraport. Cotraport of Cl- with Naâ and K+ came first to mind. Accordingly, we measured the effects of anide on traepithelial Na+, Kâ, Cl-, and fluid secretion in one series of experiments and on tubule electrophysiology in another series. Of particular interest were the effects of anide relative to those of . For this reason, we investigated the effects of anide on electrolyte secretion in -stimulated tubules, and we studied the effects of in
AJP - Cell Physiology – The American Physiological Society
Published: Sep 1, 1991
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