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Dibutyryl cAMP activates bumetanide-sensitive electrolyte transport in Malpighian tubules

Dibutyryl cAMP activates bumetanide-sensitive electrolyte transport in Malpighian tubules Na+ is subsequently extruded from the cell into the tubule lumen by an electrogenic cation pump that we and others hypothesize to be present in the apical membrane (16,17,25,26). plays the well-known second messenger role, in this case for the mosquito natriuretic peptide (MNP), which we have purified from mosquito heads (4,22-24). MNP, like , is a potent stimulator of traepithelial NaCl and fluid secretion but not of K+ secretion (4, 22, 31). The mechanisms of traepithelial K+ secretion are unknown. Furthermore, it is unknown which tracellular pathways Cl- takes when accompanying traepithelial Na’ and K+ secretion. Failing to observe Clconductances in the basolateral membrane as large as those of K+ and Na’ conductances (27), we have examined this epithelium for evidence of electroneutral Cltraport. Cotraport of Cl- with Na’ and K+ came first to mind. Accordingly, we measured the effects of anide on traepithelial Na+, K’, Cl-, and fluid secretion in one series of experiments and on tubule electrophysiology in another series. Of particular interest were the effects of anide relative to those of . For this reason, we investigated the effects of anide on electrolyte secretion in -stimulated tubules, and we studied the effects of in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Cell Physiology The American Physiological Society

Dibutyryl cAMP activates bumetanide-sensitive electrolyte transport in Malpighian tubules

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Publisher
The American Physiological Society
Copyright
Copyright © 1991 the American Physiological Society
ISSN
0363-6143
eISSN
1522-1563
Publisher site
See Article on Publisher Site

Abstract

Na+ is subsequently extruded from the cell into the tubule lumen by an electrogenic cation pump that we and others hypothesize to be present in the apical membrane (16,17,25,26). plays the well-known second messenger role, in this case for the mosquito natriuretic peptide (MNP), which we have purified from mosquito heads (4,22-24). MNP, like , is a potent stimulator of traepithelial NaCl and fluid secretion but not of K+ secretion (4, 22, 31). The mechanisms of traepithelial K+ secretion are unknown. Furthermore, it is unknown which tracellular pathways Cl- takes when accompanying traepithelial Na’ and K+ secretion. Failing to observe Clconductances in the basolateral membrane as large as those of K+ and Na’ conductances (27), we have examined this epithelium for evidence of electroneutral Cltraport. Cotraport of Cl- with Na’ and K+ came first to mind. Accordingly, we measured the effects of anide on traepithelial Na+, K’, Cl-, and fluid secretion in one series of experiments and on tubule electrophysiology in another series. Of particular interest were the effects of anide relative to those of . For this reason, we investigated the effects of anide on electrolyte secretion in -stimulated tubules, and we studied the effects of in

Journal

AJP - Cell PhysiologyThe American Physiological Society

Published: Sep 1, 1991

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