Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
WITH sickle cell disease, certain subsets of red blood (SS RBC) exhibit depletion and cellular dehydration (12-15, 21, 22). The resultant increase in hemoglobin concentration greatly accelerates the rate of polymerization of hemoglobin S (HbS) on deoxygenation (11). In animal models, dense sickle are selectively trapped in the peripheral vasculature and mediate vasoocclusion (12, 27), and in sickle cell patients the dense cell fraction is selectively lost during clinical pain episodes (1, 12). Thus cellular dehydration appears to contribute to the pathophysiology of the sickling syndromes (2 1). Three transport pathways are considered potential mediators of SS RBC dehydration in vivo: 1) a deoxygenation-induced pathway mediating passive of Na+ and K+ as well as and Mg2+; 2) the -dependent K+ channel, activated by deoxygenation-induced influx; and 3) the K-Cl cotransporter. High levels of K-Cl cotransport can be demonstrated in SS RBC (7,8); the cotransporter can be activated in oxygenated SS RBC by relatively mild acidic conditions that may prevail in part of the circulation (7), but it is inhibited by deoxygenation (8). Recent data from our laboratory 0363-6143/95 $3.00 Copyright o 1995 suggest that K-Cl cotransport may mediate the deoxygenation-independent dehydration of some SS RBC reticulocytes (15). The
AJP - Cell Physiology – The American Physiological Society
Published: Aug 1, 1995
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.