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Coupling between transepithelial Na transport and basolateral K conductance in renal proximal tubule

Coupling between transepithelial Na transport and basolateral K conductance in renal proximal tubule THE DOGMA The central dogma to be addressed is that alterations in renal proximal transepithelial sodium transport lead to parallel alterations in basolateral macroscopic potas1 When we refer to a macroscopic conductance, we refer to the conductance as a function of both permeability and ion concentration across the membrane as defined by the Goldman-Hodgkin-Katz equation. Physiological Society F517 in cell volume and maintain cell homeostasis. The effecters of such regulation could be 1) the sodium entry 0363-6127/94 $3.00 Copyright o 1994 the American F518 Na+ F7+ Glucose sium conductance. The evidence for this comes mainly from two types of experiments. Alterations in Apical Sodium Entry The first strong evidence that the basolateral macroscopic potassium conductance of an epithelium was enhanced in response to increased transepithelial sodium transport came from experiments in Necturus small intestine (31, 33). That the same situation occurred in the renal proximal tubule was first demonstrated in Necturus proximal tubule, in which it was found that a large drop in luminal sodium concentration (to reduce apical sodium entry) led to a fall in basolateral potassium transference number (tk), suggestive of a fall in absolute potassium conductance (61). This finding was extended in frog proximal tubule http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Renal Physiology The American Physiological Society

Coupling between transepithelial Na transport and basolateral K conductance in renal proximal tubule

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Publisher
The American Physiological Society
Copyright
Copyright © 1994 the American Physiological Society
ISSN
0363-6127
eISSN
1522-1466
Publisher site
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Abstract

THE DOGMA The central dogma to be addressed is that alterations in renal proximal transepithelial sodium transport lead to parallel alterations in basolateral macroscopic potas1 When we refer to a macroscopic conductance, we refer to the conductance as a function of both permeability and ion concentration across the membrane as defined by the Goldman-Hodgkin-Katz equation. Physiological Society F517 in cell volume and maintain cell homeostasis. The effecters of such regulation could be 1) the sodium entry 0363-6127/94 $3.00 Copyright o 1994 the American F518 Na+ F7+ Glucose sium conductance. The evidence for this comes mainly from two types of experiments. Alterations in Apical Sodium Entry The first strong evidence that the basolateral macroscopic potassium conductance of an epithelium was enhanced in response to increased transepithelial sodium transport came from experiments in Necturus small intestine (31, 33). That the same situation occurred in the renal proximal tubule was first demonstrated in Necturus proximal tubule, in which it was found that a large drop in luminal sodium concentration (to reduce apical sodium entry) led to a fall in basolateral potassium transference number (tk), suggestive of a fall in absolute potassium conductance (61). This finding was extended in frog proximal tubule

Journal

AJP - Renal Physiology – The American Physiological Society

Published: Apr 1, 1994

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