Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
York 10461 Nordin, Charles, and Zhen Ming. Computer model current-induced afterdepolarizations in guinea pig ventricular myocytes. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H2440-H2459, 1995.-We tested the ability a computer model transmembrane current and intracellular Ca2+ flux in the isolated guinea pig myocyte (Nordin, C., Am. J. PhysioZ. 265 (Heart Circ. PhysioZ. 34): H2117-H2136, 1993) to reproduce data from prior experimental studies and new data presented in this study regarding the behavior afterdepolarizations induced by constant inward current, a response closely related to the effect localized injury currents in damaged myocardial syncytia. The goals the study were to confirm the modelâs capacity to reproduce relevant experimental responses for which it was not originally designed and to analyze the mechanisms underlying the experimental phenomena. Under normal conditions, currentinduced afterdepolarizations in the model developed only from membrane potentials associated with L-type Ca2+ channel window current, and the magnitude upstrokes was unaffected by blockade either delayed rectifier K+ current or sarcoplasmic reticulum Ca2+ release. After Ca2+ loading secondary to either reduced extracellular [K+] or inhibition Na+-K+-adenosinetriphosphatase activity, the threshold potential for current-induced afterdepolarizations in the model, as with experimental myocytes, shifted to membrane potentials negative to the threshold potential for
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Jun 1, 1995
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.