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Computer model of current-induced early afterdepolarizations in guinea pig ventricular myocytes

Computer model of current-induced early afterdepolarizations in guinea pig ventricular myocytes York 10461 Nordin, Charles, and Zhen Ming. Computer model current-induced afterdepolarizations in guinea pig ventricular myocytes. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H2440-H2459, 1995.-We tested the ability a computer model transmembrane current and intracellular Ca2+ flux in the isolated guinea pig myocyte (Nordin, C., Am. J. PhysioZ. 265 (Heart Circ. PhysioZ. 34): H2117-H2136, 1993) to reproduce data from prior experimental studies and new data presented in this study regarding the behavior afterdepolarizations induced by constant inward current, a response closely related to the effect localized injury currents in damaged myocardial syncytia. The goals the study were to confirm the model’s capacity to reproduce relevant experimental responses for which it was not originally designed and to analyze the mechanisms underlying the experimental phenomena. Under normal conditions, currentinduced afterdepolarizations in the model developed only from membrane potentials associated with L-type Ca2+ channel window current, and the magnitude upstrokes was unaffected by blockade either delayed rectifier K+ current or sarcoplasmic reticulum Ca2+ release. After Ca2+ loading secondary to either reduced extracellular [K+] or inhibition Na+-K+-adenosinetriphosphatase activity, the threshold potential for current-induced afterdepolarizations in the model, as with experimental myocytes, shifted to membrane potentials negative to the threshold potential for http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Computer model of current-induced early afterdepolarizations in guinea pig ventricular myocytes

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Publisher
The American Physiological Society
Copyright
Copyright © 1995 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
See Article on Publisher Site

Abstract

York 10461 Nordin, Charles, and Zhen Ming. Computer model current-induced afterdepolarizations in guinea pig ventricular myocytes. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H2440-H2459, 1995.-We tested the ability a computer model transmembrane current and intracellular Ca2+ flux in the isolated guinea pig myocyte (Nordin, C., Am. J. PhysioZ. 265 (Heart Circ. PhysioZ. 34): H2117-H2136, 1993) to reproduce data from prior experimental studies and new data presented in this study regarding the behavior afterdepolarizations induced by constant inward current, a response closely related to the effect localized injury currents in damaged myocardial syncytia. The goals the study were to confirm the model’s capacity to reproduce relevant experimental responses for which it was not originally designed and to analyze the mechanisms underlying the experimental phenomena. Under normal conditions, currentinduced afterdepolarizations in the model developed only from membrane potentials associated with L-type Ca2+ channel window current, and the magnitude upstrokes was unaffected by blockade either delayed rectifier K+ current or sarcoplasmic reticulum Ca2+ release. After Ca2+ loading secondary to either reduced extracellular [K+] or inhibition Na+-K+-adenosinetriphosphatase activity, the threshold potential for current-induced afterdepolarizations in the model, as with experimental myocytes, shifted to membrane potentials negative to the threshold potential for

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: Jun 1, 1995

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