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SINGH, ASHVANI K., GLARIK, RUOPING WANG, B. AFINK, CHARLES ROBERT J. BRIDGES. 4,4â-dinitro-stilbene-2,2â-disulfonic acid; 2-[ (2-cyopentyl-6,7dichloro-2,3-dihydro-2-methyl-I-oxo-lH-inden-5-yl)oxy] acetic acid; 5-nitro-2-(3-phenylpropylamino)benzoic acid; diphenylamine 2-carboxylic acid; colon; chloride secretion PLASMA MEMBRANE CHLORIDE S are important conductive pathways in vectorial transepithelial transport in both absorptive and secretory epithelia. Chloride s mediate exit from epithelial cells across the basolateral membrane of absorptive cells and the apical membrane of secretory cells. Electrophysiological data from whole cell (6,26,30,34) and single- patch-amp studies (2, 16-21, 23, 28, 32, 33) suggest that there are several different types of epithelial s. Moreover, each subtype of may be regulated separately by one or more intracellular second messengers (15, 17, 19, 26, 30). One means of further distinguishing between different types is to examine their pharmacological sensitivity to various asses of blockers. Numerous carboxylic and sulfonic organic acids have 0363-6143/91 $1.50 been tested as potential blockers of s in both epithelial and nonepithelial tissues. Greger and co-workers (12), based on their initial observation of diphenylamine-2carboxylic acid () inhibition of basolateral membrane conductance in renal tubules, performed an extensive screening of 219 compounds (31). Their structure-activity studies of the anthranilic acid (2-aminobenzoic acid) derivatives led to the development of 5 nitro-2-(3-phenylpropylamino)
AJP - Cell Physiology – The American Physiological Society
Published: Jul 1, 1991
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