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JULIUS DAVID K. ROBERT A. ABRAHAM Cardiovascular Studies Unit, Department of Animal Biology, School of Veterinary Medicine Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 MELBIN I JULIUS,DAVID K. ROBERT A. ABRAHAM . Coherence ofcardiac output with rate changes. Am. J. Physiol. 243 (Heart Circ. Physiol. 12): H499-H504, 1982.-In awake or lightly anesthetized clogs increases in heart rate (HR) induced by atria1 pacing affect cardiac output (CO) stroke volume (SV) in a predictable way that is represented by a SV-HR relationship (dSV/dHR). Under our experimental conditions where normal regulation of atrial rate was bypassed, atria1 rate was the independent variable CO SV were dependent variables. As HR is increased, CO SV are modified by reflex other circulatory regulators. The dSV/dHR relation characterized the circulatory response to increasing HR. A single dSV/dHR curve consistently predicted responses under a number of different conditions (sting, recumbent, awake, various anesthetics, P-adrenergic stimulation, or depression) thus appeared as an expression of cardiac function. Alterations of the circulation by stellate ganglion or vagal stimulation, volume loading, aortic compression, ventricular pacing were not represented by the same dSV/dHR function. The dSV/dHR function (including its linear version as reported by others for anesthetized dogs) showed
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Oct 1, 1982
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