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Cigarette smoking decreases interleukin 1 release by human alveolar macrophages

Cigarette smoking decreases interleukin 1 release by human alveolar macrophages G. P., G. K. IWAMOTO, M. M. MONICK, G. W. decreases interleukin 1 release by human . Am. J. Physiol. 256 (Cell Physiol. 25): C260-C264, 1989.-To determine whether from smokers have an abnormal interleukin 16 (IL-l) release, we obtained by broncho lavage (BAL) of otherwise healthy volunteers in three groups: nonsmokers (NS; n = II), light smokers (LS, <lo pack-yr history; n = 4) heavy smokers (HS, X0 pack-yr history; n = 9). After 24 h in culture, unstimulated (from each group) released negligible amounts of IL-l. Lipopolysaccharide (LPS) (1 pg/ml) caused release of 21.77 t 4.33 ng IL-l/lo6 cells at 24 h from NS ; IL-1 release from HS was significantly decreased (5.52 t 1.66 ng/lO” cells; P < 0.05), whereas LS released intermediate amounts (15.07 t 6.15 ng/lO” cells). Release of IL-1 from HS was also decreased after 48 72 h in culture was observed over a wide range of concentrations of LPS. The decreased amount of IL-1 in HS macrophage supernatants appeared to be due to a defect in release of IL-1 from the cells not due to a defect in production of the mediator, since total IL-1 (IL-l present in the cell lysates plus http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Cell Physiology The American Physiological Society

Cigarette smoking decreases interleukin 1 release by human alveolar macrophages

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Publisher
The American Physiological Society
Copyright
Copyright © 1989 the American Physiological Society
ISSN
0363-6143
eISSN
1522-1563
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Abstract

G. P., G. K. IWAMOTO, M. M. MONICK, G. W. decreases interleukin 1 release by human . Am. J. Physiol. 256 (Cell Physiol. 25): C260-C264, 1989.-To determine whether from smokers have an abnormal interleukin 16 (IL-l) release, we obtained by broncho lavage (BAL) of otherwise healthy volunteers in three groups: nonsmokers (NS; n = II), light smokers (LS, <lo pack-yr history; n = 4) heavy smokers (HS, X0 pack-yr history; n = 9). After 24 h in culture, unstimulated (from each group) released negligible amounts of IL-l. Lipopolysaccharide (LPS) (1 pg/ml) caused release of 21.77 t 4.33 ng IL-l/lo6 cells at 24 h from NS ; IL-1 release from HS was significantly decreased (5.52 t 1.66 ng/lO” cells; P < 0.05), whereas LS released intermediate amounts (15.07 t 6.15 ng/lO” cells). Release of IL-1 from HS was also decreased after 48 72 h in culture was observed over a wide range of concentrations of LPS. The decreased amount of IL-1 in HS macrophage supernatants appeared to be due to a defect in release of IL-1 from the cells not due to a defect in production of the mediator, since total IL-1 (IL-l present in the cell lysates plus

Journal

AJP - Cell Physiology – The American Physiological Society

Published: Feb 1, 1989

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