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21 CONCEPTS APRIL, No. 2 OF MUSCULAR CHANGING OF THE CHEMISTRY CONTRACTION JACOB SACKS of Michigan Medical Laboratory of Pharmacology, University School, Ann Arbor There is no chapter in modern physiology which presents a more interesting development than the one dealing with the nature of the chemical reactions which supply the energy for contraction of striated muscle. New discoveries, each calling for new orientations, have come In in such rapid succession as to bewilder and confuse the observer. the eight years since Hill (39) described the ârevolution in muscle physiologyâ which necessitated a complete revaluation of earlier data, there have been so many new findings that the prediction made therein: âin a few years further discoveries will lead to further drastic changeâ has been amply justified. Many of the interpretations in this field have been influenced by a conception of the Pasteur reaction that involves a significant departure from Pasteurâs statement of the relation between respiration and fermentation. In the authorized translation of Pasteurâs Etudes SW la B&%e (76) the following occurs: . . . fermentation is a chemical action . . . that takes place when these cells, ceasing to have the power of freely consuming the
Physiological Reviews – The American Physiological Society
Published: Apr 1, 1941
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