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Age-related loss of ovarian function promotes adiposity and insulin resistance in women. Estrogen (E 2 ) directly enhances insulin sensitivity and suppresses lipogenesis in peripheral tissues. Recently, the central actions of E 2 in the regulation of energy homeostasis are becoming clearer; however, the functional relevance and degree of contribution of the central vs. peripheral actions of E 2 are currently unknown. Therefore, we prepared and analyzed four groups of mice. 1 ) Control: sham-operated mice fed a regular diet, 2 ) OVX-HF: ovariectomized (OVX) mice fed a 60% high-fat diet (HF), 3 ) E2-SC: OVX-HF mice subcutaneously treated with E 2 , and 4 ) E2-ICV: OVX-HF mice treated with E 2 intracerebroventricularly. OVX-HF mice showed increased body weight with both visceral and subcutaneous fat volume enlargement, glucose intolerance, and insulin resistance. Both E2-SC and E2-ICV equally ameliorated these abnormalities. Although the size of adipocytes and number of CD11c-positive macrophages in perigonadal fat in OVX-HF were reduced by both E 2 treatments, peripherally administered E 2 decreased the expression of TNFα, lipoprotein lipase, and fatty acid synthase in the white adipose tissue (WAT) of OVX-HF. In contrast, centrally administered E 2 increased hormone-sensitive lipase in WAT, decreased the hepatic expression of gluconeogenic enzymes, and elevated core body temperature and energy expenditure with marked upregulation of uncoupling proteins in the brown adipose tissue. These results suggest that central and peripheral actions of E 2 regulate insulin sensitivity and glucose metabolism via different mechanisms, and their coordinated effects may be important to prevent the development of obesity and insulin resistance in postmenopausal women. energy expenditure insulin resistance postmenopause Copyright © 2012 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print May 1, 2012 , doi: 10.1152/ajpendo.00638.2011 AJP - Endo August 15, 2012 vol. 303 no. 4 E445-E456 » Abstract Free Full Text Free to you Full Text (PDF) Free to you All Versions of this Article: ajpendo.00638.2011v1 303/4/E445 most recent Classifications Editorial Focus Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Yonezawa, R. Articles by Sasaoka, T. PubMed PubMed citation Articles by Yonezawa, R. Articles by Sasaoka, T. Related Content Load related web page information Current Content August 15, 2012 Alert me to new issues of AJP - Endo About the Journal Calls for Papers Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2012 the American Physiological Society Print ISSN: 0193-1849 Online ISSN: 1522-1555 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview(); } catch(err) {} var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-189672-30"); pageTracker._setDomainName(".physiology.org"); pageTracker._trackPageview(); } catch(err) {}
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Aug 15, 2012
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