Cardiac torsion-strain relationships in fatigued primary biliary cirrhosis patients show accelerated aging: a pilot cross-sectional study

Kieren G. Hollingsworth , Guy A. MacGowan , Louise Morris , Matthew G. D. Bates , Roy Taylor , David E. J. Jones , Julia L. Newton , and Andrew M. Blamire

doi:10.1152/japplphysiol.00195.2012

$The autoimmune liver disease primary biliary cirrhosis (PBC) is associated with life-altering fatigue in ∼50% of patients. Previous work suggests that fatigued PBC subjects have evidence of autonomic dysfunction and may be at a higher risk of sudden cardiac death. The manifestation of this risk is not clear. This pilot study investigated whether alterations in cardiac torsion and strain could be detected in fatigued or nonfatigued early-stage PBC patients. We performed cardiac tissue tagging and anatomical cine-imaging in 13 early-stage PBC patients (including 7 with significant fatigue) and 10 control subjects to calculate cardiac torsion and strain throughout systole and diastole. From the cardiac tagging, we calculated the torsion-to-shortening ratio (TSR), a measure of subepicardial torsion exerting mechanical advantage over subendocardial shortening. Autonomic function testing was performed to evaluate baroreceptor effective index on standing. TSR was markedly increased in the fatigued PBC patients (0.70 ± 0.13) compared with both controls (0.46 ± 0.11, P = 0.002) and nonfatigued PBC patients (0.44 ± 0.12, P = 0.003). Decreased baroreceptor effective index on standing strongly correlated with increased TSR within the whole PBC group ( r = −0.71, P = 0.007). Fatigued PBC patients demonstrate a redistribution of myocardial strain characteristic of a reduced relative contribution to contraction from the subendocardium. This is analogous to the changes found in healthy aging for subjects ∼16 yr older than the fatigued PBC patients. Hence the hearts of fatigued PBC patients may be subject to processes of accelerated aging. torsion strain magnetic resonance imaging liver disease autoimmune Copyright © 2012 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print March 29, 2012 , doi: 10.1152/japplphysiol.00195.2012 Journal of Applied Physiology June 15, 2012 vol. 112 no. 12 2043-2048 » Abstract Free Full Text Free to you Full Text (PDF) Free to you All Versions of this Article: japplphysiol.00195.2012v1 112/12/2043 most recent Classifications Article Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Alert me when eletters are published Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Responses Submit a response No responses published Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Hollingsworth, K. G. Articles by Blamire, A. M. PubMed PubMed citation Articles by Hollingsworth, K. G. Articles by Blamire, A. M. Related Content Load related web page information Current Content June 15, 2012 Alert me to new issues of Journal of Applied Physiology About the Journal Calls for Papers Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2012 the American Physiological Society Print ISSN: 8750-7587 Online ISSN: 1522-1601 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview(); } catch(err) {} var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-189672-30"); pageTracker._setDomainName(".physiology.org"); pageTracker._trackPageview(); } catch(err) {}$

Cardiac torsion-strain relationships in fatigued primary biliary cirrhosis patients show accelerated aging: a pilot cross-sectional study

Kieren G. Hollingsworth , Guy A. MacGowan , Louise Morris , Matthew G. D. Bates , Roy Taylor , David E. J. Jones , Julia L. Newton , and Andrew M. Blamire

Follow Journal of Applied Physiology , Volume 112 (12): 2043 The American Physiological Society – Jun 15, 2012