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Capsaicin attenuates feeding suppression but not reinforcement by intestinal nutrients

Capsaicin attenuates feeding suppression but not reinforcement by intestinal nutrients but not School, The present study further investigated the reinforcing and satiety actions of nutrient infusions into the small intestine. Prior work demonstrates that the feeding inhibition produced by intraduodenal infusion of some nutrients (maltose, oleate) is greatly attenuated by pretreatment with (34). is a neurotoxin that produces a partial visceral deafferentation by destroying a subpopulation of small, unmyelinated sensory neurons (12). In addition to its effects on nutrient-induced feeding suppression, has been used to investigate modulation of gastric emptying by nutrients as well as ingestive responses to a variety of agents that inhibit (cholecystokinin, bombesin, glucagon, epinephrine) or stimulate (2deoxy-Dglucose, mercaptoacetate) eating (2, 14, 20, 22, 23). Whether pretreatment attenuates the reinforcing actions of nutrients is not known. If intestinal satiety and are mediated by a common nutrient feedback system, then pretreating rats with should attenuate both feeding suppression and flavor preference conditioning produced by intraduodenal nutrient infusions. Experiment 1 FEEDING-SUPPRESSIVE effects of nutrients in the gastrointestinal tract have been extensively investigated. The available evidence indicates that nutrients act both in the stomach and in the small intestine to inhibit food intake (4,34). The postabsorptive actions of nutrients also contribute to satiety (31). In addition to inhibiting http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

Capsaicin attenuates feeding suppression but not reinforcement by intestinal nutrients

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Publisher
The American Physiological Society
Copyright
Copyright © 1996 the American Physiological Society
ISSN
0363-6119
eISSN
1522-1490
Publisher site
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Abstract

but not School, The present study further investigated the reinforcing and satiety actions of nutrient infusions into the small intestine. Prior work demonstrates that the feeding inhibition produced by intraduodenal infusion of some nutrients (maltose, oleate) is greatly attenuated by pretreatment with (34). is a neurotoxin that produces a partial visceral deafferentation by destroying a subpopulation of small, unmyelinated sensory neurons (12). In addition to its effects on nutrient-induced feeding suppression, has been used to investigate modulation of gastric emptying by nutrients as well as ingestive responses to a variety of agents that inhibit (cholecystokinin, bombesin, glucagon, epinephrine) or stimulate (2deoxy-Dglucose, mercaptoacetate) eating (2, 14, 20, 22, 23). Whether pretreatment attenuates the reinforcing actions of nutrients is not known. If intestinal satiety and are mediated by a common nutrient feedback system, then pretreating rats with should attenuate both feeding suppression and flavor preference conditioning produced by intraduodenal nutrient infusions. Experiment 1 FEEDING-SUPPRESSIVE effects of nutrients in the gastrointestinal tract have been extensively investigated. The available evidence indicates that nutrients act both in the stomach and in the small intestine to inhibit food intake (4,34). The postabsorptive actions of nutrients also contribute to satiety (31). In addition to inhibiting

Journal

AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society

Published: May 1, 1996

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