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Journals Physiology Volume 25 Issue 3

The molecular mechanisms underlying Ca 2+ entry into sperm are now much more well defined thanks to direct recordings of mature sperm cells. This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearly defined function in sperm's hyperactivated motility and are essential for male fertility. We propose that physiological stimuli such as zona pellucida and cyclic nucleotides induce Ca 2+ entry through CatSper channels instead of acting on Ca V and CNG channels as previously thought. Footnotes The fertilization-related research in our laboratory has been supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development. ©2010 Int. Union Physiol. Sci./Am. Physiol. Soc.

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Calcium Signaling Through CatSper Channels in Mammalian Fertilization

Ren, Dejian; Xia, Jingsheng
Physiology , Volume 25 (3): 165
The American Physiological Society – Jun 1, 2010

More Info
  • Publisher American Physiological Society
  • Copyright Copyright © 2011 the American Physiological Society
  • ISSN 1548-9213
  • eISSN 1548-9221
  • D.O.I. 10.1152/physiol.00049.2009
  • Publisher site Get PDF  

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